1. In my opinion, I'll choose family first. Nobody can share your happiness when you get achievement in your career someday, it's no use for me.

2. Sure. That's why something happening, somebody can overcome and even develop another solution, but somebody just gives up and is dispressed. Further, people are always in learning from childhood, e.g. learning how to "walk". We fall down, and rise up.

3. Not so easy. We may meet many people everyday, but it's rare to have the same "chemistry" impacted. Make yourself to your friends.

4. Of course not. I don't believe people are cursed. You can find many examples. President A-ban maybe a good idea.