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#415393 - 2004-09-09 15:21:04 王唯工教授的論文摘要整理 *****
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
秋天了, 突然變冷又下雨, 感冒了, 迫病請假在家,
昨天去辦公室吹了一天冷氣才變嚴重的說.

在家還是繼續努力吧
除了在國家圖書館博碩士論文那邊,
可以下載王唯工教授指導學生的論文之外,
小弟整理了網路上搜尋到的論文摘要與幾篇論文 pdf 檔.

為什麼要唸這邊的論文 ? 除了氣的樂章裡面的描述之外,
真正要運用的時候得徹底搞清楚所有相關的觀念與做法,
近代生理學探討的是組織器官,
這邊透過循環中的徑向共振理論來串接中國醫學與近代醫學.

聲音也好, 光線也好, 影像也好, 大自然的象是種訊號,
而訊號透過頻譜分析可以抓出其共通規律,
易經裡面講: " 近取諸身, 遠取諸物. "
天人想要合一, 總要有共通的東東可以合吧 ?

從最初的受精卵開始, 到媽媽的肚子, 到家人, 到學校公司團體,
到國家, 到亞洲美洲歐洲, 到地球, 到太陽系,
或許從大爆炸之後的原點就循著" 象 "的同步,
把所有的命運因果串接在一起,

要理解象有很多種方法,
王唯工教授透過" 脈象 "研究所得到的徑向共振理論,
在" 氣的樂章 "一書裡面對內經裡面陰陽五行打下了重要基礎,
或許可以當作是個出發的原點吧

這邊的論文, 像 IEEE Transaction 上面的,
只要一篇就可以畢業一個博士了說,
當年組上有很多很多人過不了這個標準而畢不了業說.

-----------

IEEE Trans Biomed Eng. 2004 Jan;51(1):193-5. Related Articles, Links


Comment in:
IEEE Trans Biomed Eng. 2004 Jan;51(1):196-7.

The natural frequencies of the arterial system and their relation to the heart rate.

Lin Wang YY, Jan MY, Shyu CS, Chiang CA, Wang WK.

Department of Physics, National Taiwan Normal University, no. 88, Sec. 4, Ting-Chou Rd., Taipei 116, Taiwan. yuhying@phy03.phy.ntnu.edu.tw

We assume the major function of the arterial system is transporting energy via its transverse vibration to facilitate the blood flowing all the way down to the microcirculation. A highly efficient system is related to maintaining a large pressure pulse along the artery for a given ventricular power. The arterial system is described as a composition of many infinitesimal Windkessels. The strong tethering in the longitudinal direction connects all the Windkessels together and makes them vibrate in coupled modes. It was assumed that at rest condition, the arterial system is in a steady distributed oscillatory state, which is the superposition of many harmonic modes of the transverse vibration in the arterial wall and the adherent blood. Every vibration mode has its own characteristic frequency, which depends on the geometry, the mass density, the elasticity, and the tethering of the arterial system. If the heart rate is near the fundamental natural frequency, the system is in a good resonance condition, we call this "frequency matching." In this condition, the pulsatile pressure wave is maximized. A pressure wave equation derived previously was used to predict this fundamental frequency. The theoretical result gave that heart rate is proportional to the average high-frequency phase velocity of the pressure wave and the inverse of the animal body length dimension. The area compliance related to the efficiency of the circulatory system is also mentioned.

------

Pacing Clin Electrophysiol. 2003 Jan;26(1 Pt 1):36-43. Related Articles, Links


Influencing the heart rate of rats with weak external mechanical stimulation.

Hsiu H, Jan MY, Wang YY, Wang WK.

Department of Electric Engineering, National Taiwan University, Taipei, Taiwan.

The ventricular-arterial coupling is assumed to minimize the expenditure of cardiac energy. From the conjecture of the resonance theory, the arterial system transmits pressure waves and resonates with the heartbeat, therefore, the arterial system is similar to a mechanical resonator. Theoretically, the heart rate can be paced with weak external mechanical stimulation and corresponding blood pressure changes can be observed. A waterbed was activated to generate 0.5-mmHg pressure vibrations as a stimulus and the rate was set to deviate 5% from the control heart rate. Among 13 studies on seven rats, the linear regression between X (stimulation frequency--control heart rate) and Y (actual changes of the heart rate) is Y = 0.992X = 0.062 (Hz) with a correlation coefficient of 0.97 (Y = X implies complete steering). The intercorrelation coefficient between the change in mean blood pressure and the heart rate was 0.79. The study showed that this weak mechanical stimulation influences the heart rate, and the blood pressure changes according to the heart rate. Cardiovascular optimization and the resonance theory may explain the way one may regulate the heart rate and the blood pressure of humans noninvasively in the future.

----

Acta Pharmacol Sin. 2003 Feb;24(2):145-51. Related Articles, Links


Evaluation of herbal formulas by pulse analysis method.

Wang WK, Hsu TL, Bau JG, Wang-Lin YY.

Biophysics Laboratory, Institute of Physics, Academia Sinica, Nankang, Taipei, Taiwan 11529, China.

AIM: To distinguish the component difference between two similar herbal formulas by pulse analysis method. Many Chinese herbs were found to have specific effects on the Fourier components of the blood pressure pulse; it might infer a specific blood redistribution process on the body and reflect the health conditions of specific organs or tissues. The pulse effect of an herbal formula was similar to the linear combination of all its herbal compositions. METHODS: Two different versions of the herbal formula Liu-Wei-Dihuang were fed to the Wistar rats as a single blind test. The blood pressure pulses on the rat tail artery were recorded and then transformed to the frequency domain by Fourier analyzer. RESULTS: Formula A, Bai-Wei-Dihuang, with two more herbs Cortex Cinnamomi and Radix Aconiti added to Liu-Wei-Dihuang, increased the harmonic proportion of the 1st harmonic (C1) but decreased C4, C5. Formula B is composed in the same way but without Rhizoma Batatatis and Poria cocos; it increased the DC of the pulse spectrum (C0), but decreased C2, C3, C4, C5, C6. CONCLUSION: The component adjustment of an herbal formula could be distinctly and quantitatively detected by pulse analysis method.

-------

Am J Chin Med. 2000;28(2):279-89. Related Articles, Links


Influence of spleen meridian herbs on the harmonic spectrum of the arterial pulse.

Wang WK, Bau JG, Hsu TL, Wang YY.

Biophysics Lab, Institute of Physics, Academia Sinica, Nankang, Taipei, Taiwan.

Pulse analysis is a powerful method in Chinese medicine. We suggest that the effect of herbal medicine is to redistribute the blood to organs and meridians. In this report, by injecting extracts into rats and then analyzing the blood pressure wave measured at the caudate arteries, we studied eight important spleen meridian related herbs: They were Semen Lablab, Fructus Amomi Globosi, Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Tuber Pinelliae, Radix Codonopsitis, Pericarpium Aurantii and Rhizoma Polygonati. All eight herbs increased the intensity of the 3rd harmonic (C3) of the pressure pulse which is correlated to the spleen and spleen meridian, as described in traditional Chinese medical literature. All of them also increased the 2nd harmonic (which is correlated to the kidney and the kidney meridian) as well as decreased the heart load (DC term of pressure wave, C0). Tuber Pinelliae, Radix Codonopsitis, Pericarpium Aurantii and Rhizoma Polygonati decreased the 1st harmonic (correlated to the liver meridian) significantly, while Rhizoma Atractylodis Macrocephalae only decreased C1 slightly. Except for Semen Lablab, all the others decreased the intensity of the 5th (stomach meridian) and the 7th harmonics. The effects of kidney herbs: Cortex Eucommiae and Radix Achyranthis were also shown for comparison.

--------

IEEE Eng Med Biol Mag. 2000 May-Jun;19(3):106-11. Related Articles, Links


The importance of pulsatile microcirculation in relation to hypertension.

Jan MY, Hsiu H, Hsu TL, Wang YY, Wang WK.

Department of Electrical Engineering, National Taiwan University.


------

IEEE Trans Biomed Eng. 2000 Mar;47(3):313-8. Related Articles, Links


Effect of length on the fundamental resonance frequency of arterial models having radial dilatation.

Wang YY, Lia WC, Hsiu H, Jan MY, Wang WK.

Department of Physics, National Taiwan Normal University, Taipei, R.O.C. wkwang@phys.sinica.edu.tw

The pressure wave moving along an elastic artery filled with blood was examined as a moving Windkessel having a natural oscillation angular frequency nu 0 and a damping coefficient b. The radial directional motion for an element of the wall segment and the adherent fluid was considered. This equation was solved with conditions at both ends of an artery of length L. An external impulse force was applied at one end and a static pressure Po at the other. Analytic solution allowed only certain oscillation modes of resonance frequencies fn, where fn2 = a + cnL-2 with [formula: see text] and V infinity is the high frequency phase velocity. The relationship between f0 and L was examined experimentally for tubes constructed of latex, rubber, or dissected aorta. The effect of raising the static pressure P0 or increasing the tension in the tube was consistent with the prediction. The hypertension that accompanies an augmentation in arterial wall and the association between the heart rate and the mean blood pressure were discussed.

--------

IEEE Eng Med Biol Mag. 1999 Jan-Feb;18(1):73-5. Related Articles, Links


Pulse analysis of patients with severe liver problems. Studying pulse spectrums to determine the effects on other organs.

Lu WA, Wang YY, Wang WK.

Department of Electrical Engineering, National Taiwan University.

Publication Types:
Clinical Trial

-------

Am J Chin Med. 1998;26(1):73-82. Related Articles, Links


Liu-wei-dihuang: a study by pulse analysis.

Wang WK, Hsu TL, Wang YY.

Biophysics Laboratory, Academia Sinica, Taipei, Taiwan.

Pulse analysis method was used in studying the traditional Chinese formula Liu-Wei-Dihuang as well as five of its main components (Rehmannia glutinosa, Cornus officinalis, Paeonia Suffruticosa, Poria cocos and Alisma plantogo-aquatica var oriental). Based on our recently developed resonance theory, we tried to elucidate the mechanism and mutual reactions of these meridian related herbs. Hot water herbal extracts were injected intraperitoneally into rats and the pressure pulse spectrum at the caudate artery was measured. The results of this study indicated that Liu-Wei-Dihuang mildly increased blood flow to meridians with lower resonance frequency: namely the liver C1, the kidney C2 and the spleen C3; but decreased blood flow to the higher resonance frequency organs and meridians: the lung C4, the stomach C5, the gall bladder C6, and the bladder C7. It also decreased the heart load C0. All of the five herb components increased blood flow to the kidney C2 and the spleen C3; but their effects on the high frequency organs varied. Alisma plantogo-aquatica var. oriental decreased the C0, C5, C6, C7; Poria cocos decreased C1, C4, C5, C6; Rehmannia glutinosa, Paeonia Suffruticosa decreased C0, C4, C5, C6, C7; Cornus officinalis increased C4 but decreased C0, C5, C6, C7.

-------

Am J Chin Med. 1997;25(3-4):357-66. Related Articles, Links


Pulse spectrum study on the effect of sie-zie-tang and Radix aconiti.

Wang WK, Hsu TL, Chiang Y, Wang YY.

Biophysics Laboratory, Academia Sinica, Taipei, Taiwan.

Extracts of the traditional Chinese formula Sie-Zie-Tang as well as one of its main components, Radix Aconiti were injected into rats intraperitoneally to observe pressure wave spectrum changes at the caudate artery. We found that Radix Aconiti decreased the C0 (DC term of the pulse), C5 and C6 (the harmonic proportions of the 5th and the 6th harmonic), but increased C2 and C3 (the harmonic proportions of the second and the third harmonic) significantly. For Sie-Zie-Tang, the increases of C2, C3, and C4 were accompanied by the decreasing of C0. The decreases of C5, C6 were small and not significant. The additional ingredients in the formula reduce toxic side effects (arrhythmia or heart failure caused by faster and stronger heart beat) due to Radix Aconiti. For human subjects, low dose Sie-Zie-Tang tends to normalize the Fourier components of the pressure wave. Orally taking the formula elevates the harmonic proportion of the harmonic that is lower than normal, but suppresses the higher one. Our results provides a possible mechanism for heart meridian related herbs. It strengthens heart beats, and normalizes energy distribution to different meridians. The study on Sie-Zie-Tang reveals another formula construction to reduce toxic side effects.

Publication Types:
Clinical Trial

--------

IEEE Eng Med Biol Mag. 1997 Jan-Feb;16(1):51-6. Related Articles, Links


Pressure wave propagation in arteries. A model with radial dilatation for simulating the behavior of a real artery.

Wang YY, Chang CC, Chen JC, Hsiu H, Wang WK.

Dept. of Physics, National Taiwan Normal University, Taipei.

--------

The importance of pulsatile microcirculation in relation to hypertension
Ming-Yie Jan Hsin Hsiu Tse-Lin Hsu Yuh-Ying Lin Wang Wei-Kung Wang
Dept. of Electr. Eng., Nat. Taiwan Univ., Taipei ;
This paper appears in: Engineering in Medicine and Biology Magazine, IEEE

Publication Date: May/Jun 2000
On page(s): 106-111
Volume: 19, Issue: 3
ISSN: 0739-5175
References Cited: 26
CODEN: IEMBDE

--------------------------------------------------------------------------------
Abstract:
The aim of the study presented was to prove that increased pulsatile blood pressure (PBP) increases perfusion in peripheral vascular beds (PVBs). We used a laser Doppler flowmeter (LDF) to measure surface renal cortical flux (RCF) and a pressure-tip transducer catheter to measure abdominal aortic blood pressure (AABP). Besides demonstrating the relationship between RCF and AABP by linear regressive analysis with an averaged periodogram (AP), we also used time-domain pulse averaging to clarify the pulsatile AABP and RCF. Furthermore, we define a flux-to-pressure-area ratio (FPAR) to evaluate the efficiency by which the pulsatile AABP drives RCF

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The natural frequencies of the arterial system and their relation to the heart rate
Yuh-Ying Lin Wang Ming-Yie Jan Ching-Show Shyu Chi-Ang Chiang Wei-Kung Wang
Dept. of Phys., Nat. Taiwan Normal Univ., Taipei, Taiwan;
This paper appears in: Biomedical Engineering, IEEE Transactions on

Publication Date: Jan. 2004
On page(s): 193- 195
Volume: 51, Issue: 1
ISSN: 0018-9294

--------------------------------------------------------------------------------
Abstract:
We assume the major function of the arterial system is transporting energy via its transverse vibration to facilitate the blood flowing all the way down to the microcirculation. A highly efficient system is related to maintaining a large pressure pulse along the artery for a given ventricular power. The arterial system is described as a composition of many infinitesimal Windkessels. The strong tethering in the longitudinal direction connects all the Windkessels together and makes them vibrate in coupled modes. It was assumed that at rest condition, the arterial system is in a steady distributed oscillatory state, which is the superposition of many harmonic modes of the transverse vibration in the arterial wall and the adherent blood. Every vibration mode has its own characteristic frequency, which depends on the geometry, the mass density, the elasticity, and the tethering of the arterial system. If the heart rate is near the fundamental natural frequency, the system is in a good resonance condition, we call this "frequency matching". In this condition, the pulsatile pressure wave is maximized. A pressure wave equation derived previously was used to predict this fundamental frequency. The theoretical result gave that heart rate is proportional to the average high-frequency phase velocity of the pressure wave and the inverse of the animal body length dimension. The area compliance related to the efficiency of the circulatory system is also mentioned.


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廣告
#415394 - 2004-09-09 15:43:55 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
-------------

第 56 筆
國家圖書館索書號: 系統編號: 71NCKU4442035
     出版年: 民7202
     研究生: 楊明興
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 神經束引發式傳導狀態之記錄與分析
    論文名稱: RECORDING AND ANALYSIS OF THE EVOKED CONDUCTION STATES IN
A NERVE BUNDLE
    指導教授: 王唯工
曾繼紹
    學位類別: 博士
    校院名稱: 國立成功大學
    系所名稱: 電機工程學研究所
     學年度: 71
     語文別: 中文
    論文頁數: 108
全文影像: (依著作權法相關規定,以下全文影像僅限國家圖書館館內下載)
目錄
中文摘要
英文摘要
謝誌
表目錄
圖目錄
1. 前言
2. 神經電訊號的記錄與分析
2-1 何以採用細胞外神經電訊號記錄法
2-2 實驗樣本之製備
2-3 神經電訊號記錄電極之設計
2-4 神經電訊號引發系統
2-5 神經電訊號記錄系統之設計
2-6 神經電訊號之記錄程序
2-7 電雜訊的衰減
2-8 電刺激雜波之消除
2-9 活體上神經束引發式神經電訊號實驗系統
2-10 數據分析
3. 結果
4. 討論
5. 結論
6. 參考資料
7. 附錄
研究生個人資料
附圖
附表

--------------

第 58 筆
國家圖書館索書號: 系統編號: 69NCKU4442077
     研究生: 鄭國順 Zheng, Guo-Shun
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 重複性電刺激對神經束內神經纖維電交互作用之研究
    指導教授: 王唯工 Wang, Wei-Gong
曾繼紹 Zeng, Ji-Shao
    學位類別: 碩士
    校院名稱: 國立成功大學
    系所名稱: 電機工程研究所
     學年度: 69
     語文別: 中文
     關鍵字: 重複性 ELECTRICAL-ENGINEERING
電刺激
神經束
神經
纖維

交互作用
電機工程
[摘要]
本論文共一冊, 內分六章; 第一章概論, 第二章數學導引, 第三章實驗裝置與雜訊降
低, 第四章結果與分析, 第五章討論, 第六章結論與展望。
本文提出一實驗裝置以研究重複性電刺激對神經束信號之影響, 和一電路模型以簡化
神經纖維電交互作用導引過程。電路模型中, 係以等效電路來模擬未引發之神經纖維
; 並且詳細討論一同電刺激周期對神經纖維之影響。實驗裝置中, 我們設計的電極和
電子隔離器能夠良好地記錄神經束集中。當神經纖維電效互作用發生時, 可用映圖法
將神經束中等效激發點之偏移算出。從實驗結果可知, 神經纖維發生電效互作用並不
顯著, 和不同速率之神經纖維被激發的數目分佈亦並無顯著變化。
↑回到頂端↑
#415395 - 2004-09-09 15:44:50 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
---------------

第 54 筆
國家圖書館索書號: 410.35 010M 82-17 系統編號: 73YM002530002
     研究生: 詹明宜
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 共振對血壓波影響之模擬
    論文名稱: The simulation of the resonance effect on blood pressure
    指導教授: 王唯工
    學位類別: 碩士
    校院名稱: 國立陽明大學
    系所名稱: 醫學工程研究所
     學年度: 73

----------------

第 55 筆
國家圖書館索書號: 系統編號: 71NCKU4442001
     研究生: 伍孝鵬 Wu, Xiao-Peng
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 不正常心電圖錄存之研究
    指導教授: 王唯工 Wang, Wei-Gong
曾繼紹 Zeng, Ji-Shao
    學位類別: 碩士
    校院名稱: 國立成功大學
    系所名稱: 電機工程研究所
     學年度: 71
     語文別: 中文
     關鍵字: 心電圖 ELECTRICAL-ENGINEERING
自動記錄系統
自我識別
調頻
電機工程
[摘要]
本文旨在發展一套新式的心電圖自動記錄系統和提出一「自我辨別」的處理方法。
心電圖自動記錄系統係應用調頻的技巧,將心電圖信號先錄於止式錄音帶上,而後輸
入「蘋果二號」微電腦中加處理。通常標準心電圖信號的導引與取得方法非常繁複也
不實用,但是應用「自我辨別」的處理方法可以避免此一問題,而且藉此方法處理的
輸體程式十分簡潔且易於增添與修改。
總言之,本系統的優點如下:低成本高效率有彈性,易於擴充,和非常容易
將體積縮小。經過一百多個個案測試後顯示,本系統的操作令人滿意,是個可行和有
效的系。

-----------

第 57 筆
國家圖書館索書號: 系統編號: 69NCKU4442035
     研究生: 雷志華 Lei, Zhi-Hua
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 神經束引發式多重動作電位之測量記錄與初步處理
    指導教授: 王唯工 Wang, Wei-Gong
張俊彥 Zhang, Zun-Yan
    學位類別: 碩士
    校院名稱: 國立成功大學
    系所名稱: 電機工程研究所
     學年度: 69
     語文別: 中文
     關鍵字: 神經束 ELECTRICAL-ENGINEERING
引發式
多重動作電位
測量記錄
初步處理
電機工程
[摘要]
 本論文主要述及從青蛙坐骨神經束表面記錄並分辨多重動作電位的可行性之初步實
 驗。其間記錄訊號用之電極經過一再的修正,最後設計並裝配完成一袖口型電極組
 。它包含位於不同兩截面的兩組電極排列,每一組有三根等距地分佈在袖口圓周上
 之電極線。將此電極組套於青蛙之坐骨神經上靠近小腿的部份,並將一對刺激電極
 與靠近脊椎骨的神經束分枝接觸,再分別刺激各神經分枝,並由電極組上記錄得傳
 過背根神經節的各個動作電位。
 初步分析所記錄得的訊號發覺刺激不同之神經分枝束所記錄得的動作電位存在很顯
 著的差異。另外假像的來源與消除之方法,記錄與刺激電路系統之設計與各種訊號
 儲存的方式之比較在本論文中亦均有詳細的討論。
 #2811306
 #2811306
↑回到頂端↑
#415396 - 2004-09-09 15:45:36 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 52 筆
國家圖書館索書號: 410.35 010M 79-1 系統編號: 78YM002530011
     研究生: 黃世君 HUANG,SHI-JUN
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 迷你化把脈機之設計及脈波頻譜分析
    指導教授: 王唯工 WANG,WEI-GONG
    學位類別: 碩士
    校院名稱: 國立陽明大學
    系所名稱: 醫學工程研究所
     學年度: 78
     語文別: 中文
     關鍵字: 迷你化 LCD-LADTOP-COMPUTER
把脈機 A/D-CONVERTER
脈波頻譜
膝上型電腦
類比/ 數位轉換器
富立葉轉換
[摘要]
以手指按脈診斷,屬於一種玄妙藝術,欲求其精,非十年不為功。批評者常責脈診為
“不科學”(即不客觀)。根據我們研究,此種中醫藝術,可藉緊湊電子裝置予以計量
化。我們研究的原理,乃是連用王唯工教授的經絡動脈樹共振理論,設計出一套脈波
微處理機控制系統,以收怪,分析并高綠人之脈波。
目前的把脈 分析系統,一般都是以個人電腦(16 位元PC) 或膝上型電腦(LCDLAPTOP-
COMPUTER) 為主體,加上一些介面卡,來進行脈波分析工作。從實用性,價格面本方
面加以考慮,實有必要發展出一套單一獨立的微處理機控制把脈系統,非懂電腦基楚
操作者,也能使用。
本儀器裝置,選用以8088CPU制成的SRC-88C微控制系統為主體,藉由壓力感測器在寸
、關、尺部位搜集脈波波形,經祿級、次級放大器放大後,再由8 位元類比/ 數位轉
換器(A/DCONERTER) 轉換成數位訊號,由8088CPU 取入微控制系統,作鶉散富立業轉
換(DFT) 及其他數值連算,所得結果,由顯示器 (LCD)、印珍機、RS-232線路傳等輸
出。最後,再與本實驗室用膝上型電腦所發民展的可搞帶式氫脈機,作一比較分析。

------------

第 53 筆
國家圖書館索書號: 448 001D 78-6 系統編號: 77NTU02442002
     研究生: 楊順聰 YANG, SHUN-CONG
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 心臟血管系統血管叢共振特性之研究
    指導教授: 王唯工 WANG, WEI-GONG
張心湜 ZHANG, XIN-TI
郭德盛 GUO, DE-SHENG
    學位類別: 博士
    校院名稱: 國立台灣大學
    系所名稱: 電機工程研究所
     學年度: 77
     語文別: 中文
    論文頁數: 148
     關鍵字: 心臟 HEART
血管 BLOOD-VESSELS
電機 ELECTRIC
循環系統 ROTATION-SYSTEM
共振
全文影像: (依著作權法相關規定,以下全文影像僅限國家圖書館館內下載)
目次
誌謝
中文摘要
英文摘要
第一章 概論
1-1 引言
1-2 動機與問題描述
1-3 前人研究與相關文獻
1-4 本論文各章節內容
第二章 物理模式與數學說明
2-1 血管叢
2-2 物理模式
2-3 簡易數學說明
第三章 動物控制與實驗
3-1 動物控制
3-2 動物麻醉
3-3 動物手術
3-4 實驗設備
3-5 實驗步驟
第四章 資料分析
4-1 資料特性
4-2 資料組合
4-3 資料分析
第五章 結果
5-1 概說
5-2 腎動脈系統
5-3 上腸系膜動脈系統
5-4 胃動脈系統
5-5 腎與上腸系膜動脈系統
5-6 脾動脈系統
第六章 討論
6-1 共振理論概說
6-2 血管叢特性與共振
6-3 血壓波形變化與共振
6-4 心臟血管系統調適與共振特性
6-5 中醫脈診與共振
第七章 結論
參考文獻
作者簡介
圖目錄
表目錄
附圖
[摘要]
本文依簡單的物理模式,佐以動物實驗,以較為巨觀的角度,利用一些工程的理論,
將心臟與重要器官組織視同一個廣義的循環體系,提出共振的理論,就一些與心臟血
管有關的爭議性問題,提出淺薄但合理的解釋,結果發現:
(一)本文實驗雖無法明確顯示各器官組織的自然頻率,但卻發現重要的器官,如腎
臟、脾臟、胃、腸等,確實擁有不同的頻率特性。
(二)器官組織與心臟的共振理論,不僅有助於各大血管阻抗特性本質的釐清;各器
官組織共振特性的合成現象,對於主動脈複雜的阻抗模式,更能提供有效的說明。
(三)器官組織藉其共
振特性,對血壓各諧波進行選擇性的傳播與反射,因而對波形產生特定的影響,此現
象是研究血壓波形變化所不可忽略的重要因素之一。
(四)若以各器官的共振特性,配合心跳變化加以探討,則以共振條件的改變、解釋
心臟血管系統如何對環境進行調適,可以補其它理論解釋此一問題之不足。
(五)心臟血管與各器官組織間的共振現象,為中醫脈診與臟器良莠的關聯性,尋得
合適的生理支持;此外,對脈波的頻譜分析,也為中醫脈象的定量描述提供一項有力
的工具。
↑回到頂端↑
#415397 - 2004-09-09 15:46:24 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 49 筆
國家圖書館索書號: 410.35 010M 78-2 系統編號: 78YM002530002
     研究生: 尤景良 YOU,JING-LIANG
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 可攜帶式微電腦化把脈器之設計及脈波分析
    論文名稱: The design of a portable computerized pulse-feeling
monitor and pulse analysis
    指導教授: 王唯工 WANG,WEI-GONG
楊順聰 YANG,SHUN-CONG
    學位類別: 碩士
    校院名稱: 國立陽明大學
    系所名稱: 醫學工程研究所
     學年度: 78
     語文別: 中文
    論文頁數: 91
     關鍵字: 可攜帶式
微電腦化
把脈器
脈波分析
霍爾電針
脈象
[摘要]
本研究之目的,乃是運用王叭工教授的經略動脈樹共振理論,設計出一套脈波的微控
制電腦分析系統,以收取,分析記綠人之脈波。進而將此結果,與崔玖教授使用霍兩
電針診斷之結果,作一比較性驗證。
本研究所欲發展之儀器,選用以6502中央處理單元制成之微控制系統uc-1+為主體,
藉有感測器在寸,關、尺部位傀集之脈波形,經過快速富立葉轉換成數位資料,再經
守快速富立葉轉換(FFT) 及其他數值運算,所得的結果,由顯示器(電腦瑩幕CRT及印
表機)輸出。最後,由此輸出之資料,再依經絡動脈 樹共振理論推得之結果,和崔教
授的診斷結果相互比較。
故本論文,主要分為以下三個主題:
一.儀器的軟、硬體設計。
二.正常人脈波的統計與公析。
三.病人脈波公析和電兩電針診斷結果的比較。
根據上述的研究主題,本研究得到了以下的結果;微電儀化把脈器的難形機、正常人
各脈象(譜波)的參考平均值及與霍兩電針的初步比較。
參考文齴
1.Wang,Wk.Lo,Y.Y.Chieng,Y.,HSU,T.L.,andWangLin,Y.Y.:resonceoforganswithth-
eHeart.AdvancesinBiomed.Eng,.Washington,DC:Hemispere,(inpress),1988.
Wang,WK.WangLin,Y.Y,.HSU,TL.,andChing,Y,.SomeFundationofpulseFeeliinginch-
ineseMedicineAdvancesinBiomed.Eng,.Washington,DC:Hemispere,(inpress),1988.

------------

第 50 筆
國家圖書館索書號: 410.35 010M 79-9 系統編號: 78YM002530003
     研究生: 陳素女 CHEN,SU-NU
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 以表面元素分析方法研究金屬面上蛋白質的吸附 = Study of
protein adsorpt- ion on metal surface by surface analysis
    指導教授: 王唯工 WANG,WEI-GONG
    學位類別: 碩士
    校院名稱: 國立陽明大學
    系所名稱: 醫學工程研究所
     學年度: 78
     語文別: 中文
    論文頁數: 63
     關鍵字: 表面元素分析方法
金屬面
蛋白質
吸附
免疫分析
放射免疫分析法
[摘要]
目前免疫分析的常用方法,如放射免疫分析、螢光免疫分析和酵素法等,是將蛋白質
標識以放射性同位素、螢光劑表面元素分析,并藉以作為蛋白質的定性或定量分析。
本實驗想將表面元素分析技術,英文名稱為Electron Spectroscopy for Chemical
Analysis, 簡稱(ESCA)。應用於蛋白質研究領域中。
本篇論文的構想主要來自於放射免疫分析法,由於放射性同位素具有輻射盄的危險,
使得實驗手緒繁雜,增加試藥儲存及廢物處理等事項,并受到半衰期的限制,我們想
將所標識的放射性同位素改成標識普通無放射性的元素,并藉著ESCA的技術作表面元
素分析。
構成蛋白質的主要元素有碳、氮、氧、氫和硫,首先我們想從這五個蛋白質本身所具
有元素中,找出一個有用的訊號作為蛋白質定量上的指標。我們的作法是先將不同量
的Coat anti-human alpha-fetoprotein 培養在鍍鎢的蓋玻片上,讓蛋白質吸附在金
屬面上,再放入大量的蒸餾水中清洗。將沒有吸附的蛋白質洗掉,再拿去作表面元素
分析。結果發現作空白試驗時,碳和氧元素會吸附在金屬面上,而氫元素質量太小,
硫元素量太少,因此這四種元素皆不能作為蛋白的指標。由實驗結果證明,金屬面上
吸附蛋白質的量越多時,所偵測到氮的訊號越大,直到氮訊號不再增加時,即為蛋白
質吸附的飽和量。由此可知,氮元素可作為蛋白質量多寡的指標。
接著本實驗將蛋白質以無放射性的銦或碘原子來標識,在不影響蛋白質的活性下,由
表面分析結果證明,這兩種原子的訊號隨蛋白質的活性下,由表面分析結果證明,這
兩種原子的訊號隨蛋白質的增加而呈線性增加,因此這種方法可作蛋白質的定量分析
。將來這種技術不只用來分析蛋白質,希望也可以應用於研究人工臟器的表面性質、
免疫組織學、醫學或其他相關的研究領域中。

---------------

第 51 筆
國家圖書館索書號: 410.35 010M 79-3 系統編號: 78YM002530007
     研究生: 鄭明鴻 ZHENG,MING-HONG
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 心血管系統模型共振特性之研究
    論文名稱: The resonant properties study of vascular
    指導教授: 王唯工 WANG,WEI-GONG
    學位類別: 碩士
    校院名稱: 國立陽明大學
    系所名稱: 醫學工程研究所
     學年度: 78
     語文別: 中文
    論文頁數: 89
     關鍵字: 血管模型
共振特性
介面卡
步進馬達
波形
流體力學
血液流體力學
[摘要]
本研究以系統分析之方法來研究血管模型在分支處所發生的一些現象。研究中,以自
行在個人電腦上撰字之程式,經介面卡輸出控制信號來控制進達之動作,并控制與步
進馬達耦合連接油壓浦,打出所欲之波形。實驗中,以一類似脈街之壓力波形,輸出
至由彈性管、氮球所組成之血管模型,以觀察在有無支管、氮球時,其強度在頻域之
差異,發現加入支管及氮球後,其中央峰值降低,且在其較高、低頻側,比皆出現峰
值、中央峰值及等因素之變化而的不同,其結果符合王唯工教授所提出之振理論。依
此理論,變得以解釋Womersley EQ。在推導血管陰抗實數部分時與實際量測值產生差
異之原因。本研究所使用之方式,實際上也為在探討流體力學或血液流體力學的一些
現象時,提出了一個新的方法。
↑回到頂端↑
#415398 - 2004-09-09 15:47:18 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 46 筆
國家圖書館索書號: 系統編號: 82YM003521001
     研究生: 陳宗瀛 Chen, Chung-Yin
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 急性心肌梗塞患者之橈動脈脈波頻譜研究
    論文名稱: Spectral analysis of radial pulse wave in patients with
acute myocardial infarction
    指導教授: 王唯工 Wang, Wei-Kong
金鏗年 Ching, King-Nien
    學位類別: 博士
    校院名稱: 國立陽明大學
    系所名稱: 臨床醫學研究所
     學年度: 82
     語文別: 中文
     關鍵字: 醫學 MEDICINE
心肌梗塞
橈動脈
全文影像: (依著作權法相關規定,以下全文影像僅限國家圖書館館內下載)
封面
中文摘要
英文摘要
第一章緒論
第二章血管循環系統與共振理論--血液分配與灌注
第三章傅立葉轉換與動脈壓脈波頻譜研究之文獻回顧
第四章急性心肌梗塞與有效性腎血漿流量研究
第五章急性心肌梗塞患者橈動脈脈波頻譜研究
第六章結論
參考文獻
[摘要]
研究背景。根據我的指導老師王唯工教授觀察液體動態模型的運作及結果,(按:楊順聰老
師在小白鼠尾動脈所作的乃研究提供了此一液體動態模型確定的動物實驗證據 ),提出一
個理論:主動脈與相聯接的內臟器官之間可以形成相互共振。因此,理論上來看該系統與
心臟其實組成一個完整的共振迴路。我們十分想知道:這種理論與實際運作功能是否可在
臨床領域中證實?
初研究理念。本研究構思實來自於楊順聰老師的動物實驗結果。在他的動物實驗中,楊老
師發現即夾即放左側腎動脈或上腸繫膜動脈會改變小白鼠尾動脈脈波的頻譜分析。因此,
我們即思考在臨床上有那一種疾病或疾病狀態可能短暫的改變與主動脈相連的內臟器官的
血管阻力(或阻抗)與血 流。當然這部分血管阻力或血流的變化必須可用某一檢驗 室方法
來偵測得知。然後,我們期待就像在楊老師的動物 實驗一樣,某特定內臟之血管阻力或血
流量的改變,會反映 在患者橈動脈脈波的頻譜分析(藉離敬傅立葉轉換之助)。
研究方法。根據研究理念,我們分成兩階段來進行該研究。首先,我們藉用標記I-131的
iodo-ortho-hippurate 靜脈注射而在準44分鐘後自另一處抽血來測定有效性腎 血漿流量
的核子醫學檢查來研究急性但無併發症 (Killip 第一型)心肌梗塞後有效性腎血漿流量的
變化。再系列性測定心房利鈉激素或鏈胜以研究有效性腎血漿流量的變化是否與此相關。
其次,我們每日記錄急性但無併發症急性。、肌梗塞患者右手橈動脈脈波,並藉用離散傅
立葉轉換來分析是項動脈脈波之能量頻譜。這項動脈脈波能量頻譜分析更包括了三組無心
肌梗塞患者作為參考基準。
研究結果。從第一部分的研究過程,我們有下列三項結果:
(1)在12例無心肌梗塞而僅住院接受冠狀動脈攝影檢查之冠心症患者,我們證實藉用I-131
iodo-ortho-hippurate測定有效性腎血漿流量之再生性良好,係一有效且方便的檢測方法

(2)急性但無合併症之心肌梗塞發生後,患者都表現有短暫性有效性腎血漿流量增力加的現
象;
(3)上述這種短暫性有效性腎血漿流量增高,至少有一部份的原因是因於急性心肌梗塞後心
房利鈉激素或鏈胜升高的結果。
而在第二部分的研究中,我們有了以下的觀察結果:
(1)急性但無併發症之心肌梗塞後之當時,患者橈動脈脈波能量頻譜之諧頻CO會暫時降低(
雖然不具統計學有意義的降低 ),而逐漸隨心肌梗塞的恢復而回復與無心肌梗塞患者相匹
配的程度;
(2)在急性但無併發症之心肌梗塞後之當時,橈動脈波能量頻譜中諧頻C2與C3之百分比程
度(Percentag intntensity of co)會呈現短暫性的降低;而後隨急性心肌梗塞的逐日恢復
而回復其與無心肌梗塞患者相匹配的水準;
(3)急性心肌梗塞後,橈動脈脈波能量頻譜中諧頻C2與C3之百分比程度之短暫性降低與急性
心肌梗塞後有效性腎血漿流量之增加呈現有統計學意義的反向相關。
結論。Selwyn指出,局部組織或器官的血流量實在是判定該組織或器官功能正常或疾病的
重要指標。他曾藉正子閃爍電腦斷層掃描與標記C-12之人類自蛋白來偵測各重要器官,如
:腦.肝.心...等局部臟器血流。本研究可能是第一次提供數據證實急性但無併發症心肌梗
塞後有效性腎血漿流量會有短暫性升高而後逐漸降低的變化,可能是局部血管阻力減低的
結果。而心房利鈉鍊胜之短暫性升高可能是有效性腎血漿流量升高的主要因素或眾多因素
之一。而有效性腎血漿流量短暫性升高可能反映在動脈脈波能量頻譜中短暫性降低其百分
比強度之諧頻c2與c3。這個觀察事實上是首次有臨床數據顯示內臟血管阻力或血流的改變
可由往傅立葉轉換得到之動脈脈波能量頻譜分析中偵知。而這項觀察結果不但提供王老師
之液體動態模型有臨床證據,並支持王老師的理論:與主動脈相連的臟器可與主動脈形成
共振,而全一系統實乃一個共振迴路。臨床應用。本研究之臨床實用性有二:
(1)檢視動脈脈波能量頻譜分析中之諧頻C2與C3百分比強度,可作為監視急性但無併發症心
肌梗塞病程恢復順利與否之指標。
(2)急性但無併發症心肌梗塞發生後,腎血管叢對於交感神經興奮度增加的反應不同;而此
項相異的反應應與心肌梗塞後心房利鈉激素之增加相關。
Background. According to Wang et al's observation from the operation of their
dynamic fluid model, which has been further demonstrated by the Young et al's
animal study, that aorta and closely linked internal organ may cause coupled
oscillation and theoretically this integrated system together with the heart
is actually acting physiologically as a resonance circuit. We are wondering
whether this theoretical model and its function is really existing and can be
demonstrated clinically.
Rational.The idea of the study is actually from Young et al's animal
observation that briefly clamping the renal artery or the supramesentery
artery might change the power spectrum of tail arterial pulse of rat.
Therefore, we have to seek a disease condition or state which may alter the
vascular resistance or plasma flow of one internal organ which linked to
aorta, and certainly this alteration should be able to measure with existing
laboratory technique. Then, we hope we are able to see this alteration of
vascular resistance or plasma flow of this specific internal organ in the
power spectrum of patient's radial pulse derived from discrete Fourier's
transformation.
Method.The whole study is now dividing into two steps. Firstly, we are using
intravenous injection of 1-131-iodo-ortho-hippurate to measure the effective
renal plasma flow immediately after and one week after acute but uncomplicated
myocardial infarction in 17 patients. Serial measurement ofatrinatriuretic
peptide of these patients was also carried out to demonstrate whether or not
it is attributing to the alteration of effective renal plasma flow after
myocardial infarction. Secondly, we recorded the radial pulse of all these
patients with acute but uncomplicated myocardial infarction non-invasively
everyday for ten days , and studied the power spectrum of pulsewaves derived
by discrete Fourier's transformation. Three more groups of patients who are
not having myocardial infarction were as control for comparison.
Results. In the first part of the clinical study we demonstrated followings:
(1) the good reproducibility of effective renal plasma flow by using I-131-
iodo-ortho-hippurate isotopes in 12 control patients, and proved this
technique is useful and effective;
(2) the initial elevation of effective renal plasma flow immediately after
acute but uncomplicated myocardial infarction, reduced a week later; and
(3) the early elevation of atrinatriuretic peptide after myocardial infarction
may, at least partly, contribute to the initial elevation of effective renal
plasma flow.
In the second part of this clinical study we have the following observations:
(1) immediately after acute but uncomplicated myocardial infarction, the
patient may show lower intensity of harmonics CO of the power spectrum of
radial pulse, although statistically insignificant, and the intensity may
gradually return to the level compatible to those patients who did not have
acute myocardial infarction;
(2) immediately after myocardial infarction, both the harmonic C2 and C3 show
lower (statistically significant) in percentage intensity of the average
intensity of radial pulse, the CO, and gradually increased along with the
recovery of the disease in a few days;
(3) the initial drop or reduction of the percentage intensity of both harmonic
C2 and C3 of the average intensity of radial pulse, the CO, reversely
correlates with the initial elevation of the effective renal plasma flow with
statistically significant p value;
Conclusion. As Selwyn pointed out in his study of regional blood flow
distribution after acute myocardial infarction, using ll-C labeled human
albumin microsphere and PET scanning technique, that blood flow in regional
tissue is a critical determinant of function in health and disease. We are
probably the first to demonstrate that the effective renal plasma flow does
transiently increase after acute but uncornplicated myocardial infarction (
most likely due to the reduction of regional vascular resistance). The
transient elevation of atrinatriuretic peptide may play an important role for
this transient increase of effective renal plasma flow but does not alter
renal function, urine and plasma electrolytes or the urine amount. And this
transient increase of effective renal plasma flow can reflect on to the power
spectrum --reduction of the percentage intensity of both harmonic C2 and C3 --
of radial pulse, using discrete Fourier's transformation. These clinical
observations provide further related evidence in support of the finding of
dynamic fluid model and Wang's theory that aorta and closely organs may cause
coupled oscillation, and the structure is equivalent to a resonance circuit.
Clinical Implication.The clinical implication of this clinical study at this
moment can be twofold:
(1) non-invasive recording of radial pulse may be useful to monitor the
recovery of acute but uncomplicated myocardial infarction by checking the
percentage intensity of harmonic C2 and C3;
(2) vascular bed of kidneys may respond differently to the enhanced sympathetic
activity after acute myocardial infarction; and this unusual response may be
related to the release of atrinatriuretic peptides.

-------------

第 47 筆
國家圖書館索書號: 410.35 010M 82-13 系統編號: 81YM003530003
     研究生: 林慶波 Lin, Ching-Po
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 直流電壓在溶液中緩慢電流反應的機制
    論文名稱: The mechanism of the slow current changing induced by the
DC voltage in the solution
    指導教授: 王唯工 Wang, Wei-Kung
    學位類別: 碩士
    校院名稱: 國立陽明大學
    系所名稱: 醫學工程研究所
     學年度: 81
     語文別: 中文
     關鍵字: 醫學工程 MEDICAL-ENGINEERING
直流電壓在溶液中
緩慢電流
反應的機制
[摘要]
當一個直流電壓通過含有極性分子(polar molecCule)的溶液時,溶液中會引起何種變化?
尤其是電流如何變化,這是本文探討的重心.
溶液中影響電流反應的因子很多,我們從其中選擇了三個比較重要的項目﹕溶液中polar
molecule的濃度(考量生理的因素,選擇了lactic acid).溫度以及離子數量的多寡(選用
體內較多的離子NaCl),以此三項作為實驗控制變因,量取電流變化的圖形,並比較分析,
以從其中得到一些訊息,來瞭解溶液中發生之變化.
結果發現,溫度對電流的變化有些微影響,離子造成的反應很大但在極短時間內便迅速衰
減,而 polar mole-cule在溶液中確實主導了某一時間內的電流反應,這在生理上是否有
意義呢?當這直流電壓加在人體上時是否也有相類似的現象?此反應是否有其生理意義?是否
與低頻電磁波能量之吸收有關?尚有待追一步的努力.
What will happen when we put a DC voltage electrode into a solution with
polar molecule, especially the changing of current ? This is the main point
of the article.
There are many factors will affect the current changing in solution .
Three important factors , the concentration of the polar molecule, temperature
and the amount of the ions were manipulated. The current changing graphs 
were analyzed to get some informa- tions about the changing of the solution.
We found that temperature has little effect on currents . The ions induced
very great but quickly decayed response . What we really interested is the the
current changing induced by polar molecule which keeps for a long time and
changes very slowly. Is it meaningful to human body ? Is there a similar
pheno- menon when we add the voltage to human body ? Does this response have
its physiological meaning ? Is this concerned with the energy absorbed of
EMF ? More studies need to be done to answer all this questions.

-----------

第 48 筆
國家圖書館索書號: 448 001M 81-112 系統編號: 80NTU02442112
     研究生: 廖世舉 LIAO, SHIH-CHU
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 共振對血壓波與血流波影響之模擬
    論文名稱: The simulation of the resonance effect on blood pressure
and flow
    指導教授: 王唯工 WANG, WEI-KUNG
    學位類別: 碩士
    校院名稱: 國立台灣大學
    系所名稱: 電機工程研究所
     學年度: 80
     語文別: 中文
    論文頁數: 52
     關鍵字: 血壓波
血流波
心臟血管系統
共振耦合
[摘要]
心臟血管系統的運作非常奧妙;心臟打出血液時,面對這麼多臟器,要怎麼有效的分
配到各器官呢?整個血管系統是否有一較有利的條件來配合心臟呢?
本實驗設計,將心臟血管系統簡化至心臟和一個器官的簡單系統,臟器分別用汽球,
正常的樹狀分枝管,不正常的樹狀分枝管模擬,以觀察各種不同型態 (Pattern)的器
官,各心臟提供了什麼訊息。
實驗結果顯示,在心臟血管系統間的共振耦合下,各模擬器官對心臟輸出的血液壓力
波有選擇性,且在模擬正常的樹狀分枝血管叢時,有著最明顯的頻率選擇特性;其表
現不僅在頻域的能量大小分配上,也在其相位的變換上。
共振耦合的觀念為王唯工教授所提出,而共振耦合也是心臟血管系統有效分配血液至
各器官的答案。
↑回到頂端↑
#415399 - 2004-09-09 15:48:13 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 40 筆
國家圖書館索書號: 418.1 001M 86-8 系統編號: 85NTU00550012
     研究生: 郭玉誠 Kuo, Yu-Cheng
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 天麻鉤藤散降壓作用之研究
    論文名稱: The study of antihypertensive effects of Gastrodia and
gambir formula
    指導教授: 鄧哲明博士, 王唯工博士, 柯逢 Teng C.M., Wang W.K., Ko F.
年博士 N.
    學位類別: 碩士
    校院名稱: 國立台灣大學
    系所名稱: 藥理學研究所
      學號: R84443004
     學年度: 85
     語文別: 中文
    論文頁數: 63
     關鍵字: 鉤藤 Gastrodia
高血壓 hypertension
天麻鉤藤散 frequency analysis
頻譜分析 nifedipine
鈣離子阻斷劑 Ca channel blocker
自發性高血壓大鼠 SHR
[摘要]
中 文 摘 要  天麻鉤藤散是傳統醫學中常用來治療高血壓的中醫方劑
,其組成抱括鉤藤、天麻、石決明、黃芩、杜仲、桑寄生、山槴子、益母
草、夜交藤、淮牛膝、茯神,其中鉤藤、杜仲、益母草曾被研究證實其降
壓作用;本篇實驗的目的,在於探討天麻鉤藤散降壓作用的有效劑量,安
全性及對血管與血液流體動力的影響。  WKY大鼠口服單一劑量之天麻
鉤藤散1、3、10mg/kg具有降壓作用,最大降壓作用呈現劑量相關性(
dose-dependent effect),其收縮壓分別下降6.0%、10.7%、13.5%,降壓
作用時間1小時、1小時、3小時;30mg/kg的最大降壓作用與降壓作用時間
並未較10mg/kg增加。而100mg/kg的最大降壓作用13.3%,及降壓作用時間
(2小時)與10mg/kg相比較皆減少。  WKY大鼠每天口服二次天麻鉤藤
散四星期,發現10mg/kg組,在四星期的投藥中,均出現明顯的降壓作用
,而30與100mg/kg二組的降壓作用只出現在投藥的前二星期,之後血壓回
到正常值。  WKY大鼠在四星期的投藥後取下胸主動脈實驗,發現100
mg/kg組對phenylephrine與KC1引發的最大收縮力均較對照組增加,而對
sodium nitroprusside鬆弛作用的EC50農度則增加。  SHR大鼠口服100
mg/kg天麻鉤藤散造成一半以上的動物死亡;以3、10、30mg/kg每天口服
二次共服用四星期,可以劑量相關的降壓方式抑制血壓的惡性上升(
malignant hypertension)。在離體的胸主動脈實驗中,以KC1引發的最大
收縮力,三個劑量實驗組與對照之間亦呈現劑量相關的抑制作用。  以
傅立葉分析的方法比較天麻鉤藤散與鈣離子阻斷劑nifedipine的血壓頻譜
變化,發現天麻鉤藤散對C1-C6個諧波均有抑制的作用,而nifedipine則
只抑制C2-C6五個諧波,這些結果符合傳統醫學中關於天麻鉤藤散的歸經
敘述,同時顯示單一成分純物質的現代藥物同時具備歸經的性質。  綜
合以上結果顯示天麻鉤藤散降壓的作用應與抑制動脈收縮力有關,且對不
同諧波的血壓波皆造成抑制而達到降壓的作用,長期投藥則能阻止SHR血
壓的惡性上升。而降壓的安全劑量範圍應在1-30mg/kg之間,高於30mg/kg
的劑量可能引起血壓控制的代償反應(compensative reaction)甚至造成
休克死亡,而傳統醫學中扮演中藥使用指導角色的歸經理論,則可以透過
已知藥理機轉的純物質加以研究。
Abstract  Gastrodia and gambir formula(天麻鉤藤散)is one
ofChinese herbal drugs ofthn used as an antihypertensive
therapy.The formula is composed of gastrodia(天麻),gambir(鉤藤),
scute(黃芩),eucommia(杜仲),haliotus(石決明),loranthus(桑寄生),
gardenis(山梔子),leonurus(益母草),polygoni multiflori(夜交藤),
cyathula(牛膝),poria cocos(茯神),Gambir(鉤藤),eucommia(杜仲)and
leonurus(益母草)have been reported toexhibite the anti
hypertensive effects. The purpose of this thesis isto
investigate the antihypertensive effect, dosage, safty and
theinfluences on vascular and hemodynamic properties of
thisformula.  Single oral administration(dosel-10 mg/kg)of
this formulato WKY rats, caused a dose-dependent hypotension. At
the dose of30mg/kg, this formula increased neither the maximal
effect nor thehypotensive duration (3h), while at 100mg/kg it
decreased themaximal effect and the hypotensive duration
compared with thosecaused by 10mg/kg  When administered twice
a day, oral administration of thisformula caused a sustained
hypotension for four weeks in the groupreceiving 10mg/kg, but in
30 and 100mg/kg groups theirdepressor effects were observed only
in the first two weeks.  After a four-week treatment, we found
that the maximal effectsof high-K+ - and phenylephrine-induced
contractions of thoracicaorta was increased in the 100mg/kg
group. The EC50 value ofrelaxing effects of sodium nitroprusside
decreased also in thisgroup. However, the EC50 value of high-K+
in the group of 10mg/kg increased  In SHR rats, oral
administration of this formula at 100mg/kgcaused death in more
than half of the treated rats. At dose of 3,10and 30mg/kg, twice
a day, this formula prevented the malignanthypertension in a
dose-dependent manner. The high-K+ inducedcontraction of
thoracic aorta in SHR rats was dose-dependentinhibited.
Fourier's analysis of the blood pressure wave of ratsreceiving
this formula and nifedipine, we found this formulainhibited six(
C1-C6)harmonic components, and nifedipineinhibited five(C2-C6)
components., This result agreed with themeridian statements of
this formula it the traditional medicine, andindicated the pure
compounds used in the modern medicine alsoexhibited the meridian
properties.  These results suggest that Gastrodia & gambir
formula(天麻鉤藤散)inhibited the contraction of arteries and
reduced all theharmonic components of blood pressure wave.
Chronicadministration of this formula prevented the
malignanthypertension of SHR rats. The safe and effective dose
are estimatedto be 1 to 30 mg/kg, while higher doses may cause a
compensatoryregulation of blood pressure, even shock and death.
The meridianeffects of drugs described in traditional medicine
could be studiedwith the well-studied pure compounds.

-----------

第 41 筆
國家圖書館索書號: 448 001M 84-135 系統編號: 83NTU02442140
     研究生: 許昕 Xu, Xin
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 共振理論於長直管中流體行為之探討
    論文名稱: Study on the pressure and flow propagation in a long
cylindrical elastic tube with radial resonance theory
    指導教授: 王唯工 Wang, Wei Gong
    學位類別: 碩士
    校院名稱: 國立臺灣大學
    系所名稱: 電機工程學研究所
     學年度: 83

--------------

第 42 筆
國家圖書館索書號: 413 039M 83-8 系統編號: 82CMCH3050005
     研究生: 蘇妃亭 Su, Fei-Ting
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 原氣之測量與脈波儀對照研究
    論文名稱: The Contrast Study on the Measurement of Vitality Energy
and Pulse Spectrum Analysis by pulse Analysis Device
    指導教授: 黃維三
王唯工
    學位類別: 碩士
    校院名稱: 中國醫藥學院
    系所名稱: 中國醫學研究所
     學年度: 82
     語文別: 中文
    論文頁數: 81
     關鍵字: 原氣測量
脈波儀
[摘要]
  本研究以「原氣測量儀」來測量111位成年人(男性60人,女性51人)腹部神闕至關元
穴區的最大彈力值,以作為原強弱的客觀指標;並配合王唯工教授發明之「脈診儀」來測
量兩手寸口撓動脈之脈波,並且經由傅立葉(Fourier)軟體分析後呈現數量化的脈搏諧波
頻譜,以印證原氣之重要性,及探討原氣強弱與寸口所顯示臟腑盛衰的相關性。研究中發
現原氣隨著年齡的老化而漸衰,且男性原氣值較同年齡層的女性高,可推論原氣與老化有
關,即原氣值較高者老化較慢,而一旦老化則原氣漸衰。另外,研究中發現身體健康狀況
較佳少罹病者及肌肉壯實者原氣值較易罹病及瘦弱者高,可推論原氣強者身體抗病及氣血
生化運行能力較佳。在脈診儀對照研究方面,研究中發現原氣值與左手肝諧波血分值、右
手脾諧波氣分值、左手肺諧波氣分值及兩手肺諧波血分值有正相關,恰與「原氣可推動全
身氣血運行」之理論相符;另外,由研究樣本中發現隨著年齡的老化,心腎功能代償性亢
進,但其他臟腑則氣虛血瘀的現象漸顯;男女在臟腑諧波頻譜分析方面,氣分值大多無差
異,只有左手小腸諧波氣分值男性比女性高,在臟腑諧波血分方面,則男性在右手肺、左
手膀胱諧波血分值較女性高,但右手脾、膽、小腸諧波血分值則男性較女性低,其機理有
待進一步深入探討。除此之外,研究中發現練氣功、國術或運動者在兩手肺、右手膀胱諧
波氣分值較未練者高,但右手胃諧波氣分及血分值和右手大腸血分值則前者較後者低,提
示練氣功、國術或運動可增高肺及膀胱功能,但對消化系統之氣血循環則較不利,值得我
們重視並繼續深入研究。


[摘要]
We measure the maximal abdominal elastisity of 111 adults (60 males, 51
females) from the area of CV -8(Shenque) to CV-4(Guanyuan) as an index of the
strength of vitality energy using "Vitality Energy Measurement Device" to
eliminate human error. For proving the importance of vitality energy and
determing the corelation between vitality energy and Zang, Fu-organs, we also
use "Pulse Analysis Device" designed by Dr. Wei-Kong Wang to measure the
radial pulse waves of both wrists and translate to quantative pulse spectrum.
In adults, we find vitality energy become weaker as getting older, and the
vitality energy of male is stronger than that of female in the same age of 
adults. We also find the vitality energy is stron ger in the healthier and
stronger persons.
In pulse analysis spectrum, we find vitality ene rgy can improve the the qi
and blood circulation of Zang organs especially that of liver, spleen and
lung.  We also find the pulse spectrum of some Zang-Fu or gans is different
in different age and sex. The pulse spectrum of some Zang-Fu organs is also
different in the persons who have learned qi-gong or practiced exercise and
the persons who have not.

----------------

第 43 筆
國家圖書館索書號: 330 001M 83-1 系統編號: 82NTU02198033
     研究生: 鮑建國 Bao, Jian Guo
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 純水及氯化鈉水溶液之步級電壓響應
    論文名稱: The impulse response of pure water and saline
    指導教授: 王唯工 Wang, Wei Gong
陳義裕 Chen, Yi Yu
    學位類別: 碩士
    校院名稱: 國立臺灣大學
    系所名稱: 物理學研究所
     學年度: 82

----------------

第 44 筆
國家圖書館索書號: 448 001D 83-13 系統編號: 82NTU02442019
     研究生: 尤景良 You, Jing Liang
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 大白鼠腎臟系統共振現象之研究
    論文名稱: Resonance in the kidney system of rats
    指導教授: 王唯工 Wang, Wei Gong
    學位類別: 博士
    校院名稱: 國立臺灣大學
    系所名稱: 電機工程學研究所
     學年度: 82
全文影像: (依著作權法相關規定,以下全文影像僅限國家圖書館館內下載)
封面
目錄
第一章 緒論:
1-1 引言
1-2 論文主題
1-3 背景之回
1-4 論文之結構
第二章 共振模型、理論及其相關研究:
2-1 共掁理論之源起及概說
2-2 共掁理論之相關研究
2-2.1 五臟模型
2-2.2 單一臟器之共振模型
2-2.3 相關之動物實驗
2-3 共振電路模型及共振藕合方程式
2-3.1 共振電路模型
2-3.2 共振藕合方程式
第三章 實驗方法與設備:
3-1 實驗之簡介
3-2 麻醉藥配製
3-3 動物手術及實驗裝置
3-3.1 動物手術及感測
3-3.2 訊諕處理
3-4 步驟
第四章 結果
4-1 概說
4-2 腎臟系統阻抗
4-3 腹主動脈與腎動脈流量頻譜比較
4-4 由夾左、右、兩邊腎動脈,研究腎臟系統共振特質
第五章 討論:
5-1 藕合共振與彈性腔諧振之不同
5-2 藕合共振與稱T管模型之比較
5-3 腎臟系之共振現象
5-3.1 腎臟系統的頻率特性
5-3.2 腎臟系統頻率特性的再次檢驗
5-4 藕合共振理論的預測
5-5 藕合共振理論的中醫觀
第六章 結論:
參考文獻:
中英文字檢索:
作者簡介:
↑回到頂端↑
#415400 - 2004-09-09 15:49:04 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 36 筆
國家圖書館索書號: 330 001M 87-19 系統編號: 86NTU00198012
     研究生: 黃啟裕 Huang, Chi-Yu
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 主動脈血壓波與血流波的模擬與分析
    論文名稱: The analysis and simulation on the blood flow and
pressure wave in artery
    指導教授: 陳義裕 Y.Y. Chen
王唯工 W.K. Wang
    學位類別: 碩士
    校院名稱: 國立台灣大學
    系所名稱: 物理學系
      學號: R85222035
     學年度: 86
     語文別: 中文
     關鍵字: 主動脈 artery
血壓波 pressure wave
血流波 blood flow
相位差 phase difference
耦合振盪 coupled oscillation
血液動力學 hemodynamics
[摘要]
循環系統為維持生命的重要一環,而心臟將血液送出後即由動
脈所運送。心血管系統如何有效地分配血量至所需的各器官組織一
直是研究者所關注。


  本文利用彈性管與豬主動脈進行各種模擬與體外實驗(in vitro)
嘗試探討單一主動脈的特性。實驗結果得知單一主動脈的特徵頻率
非呈現諸諧波的關係(即一倍、二倍、三倍…等),且長度愈長的
主動脈其自然頻率愈低。流體在幫浦打出流入主動脈後,血流波領
先血壓波的角度大都從45度開始。在較長的彈性管後面可發現血壓
波反而領先血流波且角度有愈漸增大的趨勢。


  生理上,人體的脈波均呈現諧波關係,且血流波皆領先血壓波,
與單一模擬的主動脈性質不盡相同。因此我們認為動脈樹叢(器官)
之間的耦合振盪不僅會改變血壓波的頻譜也會改變血流波的分布。
所以由這些分析我們以清楚了解了單一彈性管的特性,也認知單一
彈性管對描述整個循環系統所能獲得的訊息。有了這些基礎,我們
將可更進一步探討不同特徵頻率的彈性管耦合時所能造成的效應,
以模擬器官的耦合振盪效果,期能更接近生理狀況以了解整個循環
系統的奧祕。

------------

第 37 筆
國家圖書館索書號: 448 001M 87-139 系統編號: 86NTU00442017
     研究生: 陳桂榕 Chen, Kuei-Jung
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 針刺穴道對脈波及微循環之影響-以傳輸線模型解釋
    論文名稱: The Acupuncture Effect on the Pulse Spectrum and the
Microcirculation-Interpretation byTransmission Line Model
    指導教授: 王唯工 Wang Wei-Kung
指導教授(中) 姓名:
    學位類別: 碩士
    校院名稱: 國立台灣大學
    系所名稱: 電機工程學系研究所
      學號: R84523123
     學年度: 86
     語文別: 英文
    論文頁數: 57
     關鍵字: 針刺穴道 acupuncture
血液流體力學 hemodynamics
傳輸線理論 transmission line
脈波 pulse
微循環 micro-circulation
雷射都卜勒 laser Doppler flowmeter
[摘要]
我們曾經假設經絡是一群共振的血管樹叢(即所謂的穴道),以動脈成串相連。針刺穴
道即是該血管樹叢受到壓迫,因而改變了該經絡原來之共振頻率,血壓波因而重新分配至
各經絡。過去我們已經實驗了中藥或針刺穴道對手上脈波的影響,其結果均顯示出脈波之
各共振頻率分配比率被改變了,且改變之比率狀況與中醫之古籍中之記載極為吻合。為進
一步證明我們的理論,
本篇論文分成兩個部份研究針刺穴道的影響。並根據血液流體力學
的理論,進一步提出傳輸線理論來解釋我們所得到的實驗結果。
第一個部份是針刺穴道對脈波的影響。我們發現針刺同一穴道但受試者姿勢不同於中醫之
古籍中對於取穴法之記載對脈波有不同之影響,此結果顯示了中醫之古籍中對於取穴法之
記載有著重要的參考意義。
第二部份是針刺穴道對微循環的影響。我們利用雷射都卜勒量測與針刺穴道相同、不同
經絡上的穴道點(鄰近上、下各取一個穴道)之微循環,結果發現與針刺穴道相同經絡之
穴道點在針刺之後其血流量顯著下降,而不同經絡之穴道點則無影響。此一結果與過去有
實驗顯示「與被壓迫之穴道相同經絡的穴道點其脈波壓力在壓下穴道之後均顯著下降,而
不同經絡上的穴道點則變化不明顯」之結果相當吻合。
利用傳輸線理論,我們假設動脈及靜脈是一連串的電阻、電感的組合,而中間以動脈血管
樹叢,即電容,相連接,輸入電壓則代表心臟推動血液之能量。此一傳輸線有其特定之共
振頻率,此時能量傳遞百分之百至負載。各經絡就如以各不同頻率共振之傳輸線,因此心
臟可根據其頻率選擇性分配血液。如果我們針刺穴道,相當於該傳輸線其中之電容值被改
變,則共振頻率被改變,便產生能量重新分配,因而我們可量到脈波變化;而且該經絡上
之血壓波會下降,故血流量會減少。
Previously, we proposed that each meridian is a group of resonance arterial
trees, which are acupoints, connected to the artery. Blood
pressure wave distri-
butes differently at different meridians according to its resonance frequency.
Acupuncture is like to modulating the physical properties of arterial trees,
therefore disturbing the original resonance frequency. Then the blood pressure
wave distributes differently. We had investigated both herb
treatments and acu-
puncture were able to redistribute blood around the body. The previous
investigations also showed that the therapeutic effect of
acupuncture was in coincidence with its effect on the amplitude
of the pressure pulse spectrum.
In this report, we investigated the acupuncture effects on
pulse and on micro-circulation to more improve our proportions
and proposed the resonance theory and its transmission line model
according to the hemodynamics to interpret our experiment results.
Part one is the acupuncture effects on pulse. We found that
the posture effect is related to the positions of the acupoints.
The different acupuncture effects by different postures could be
interpreted by the resonance theory or its transmission line model.
The acupoint is supposed to be a coupled arterial tree, which
behaves like the induced capacitance in the transmission lines.
It suggested that the acupoint was the vascular trees, which were
embedded in one muscle. Since the position of the muscle changes
with the posture, and so does the acupoint. This could be the
reason to the Chinese medicine textbooks emphasize the important
of posture to get the therapeutic effects of acupuncture.
Part two is the acupuncture effects on micro-circulation.
We used the laser Doppler flowmeter measuring the blood flow of
the acupoints, one of which was on the same meridian as the
acupuncture point needled and one was on the different meridian
from the acupoint needled. We found that the blood flux decreased
significantly on the same meridian that was needled and wasn't
affected much on the different meridian. The result showed that
it correspond to our previous study that when one acupuncture
point was pressed, the blood pressure intensity of the artery
decreased significantly, while it didn't react much when non-
acupoint was pressed.The resonance theory or its transmission
line model successfully solves these results. Sticking a needle
into an acupoint is similar to change the matching capacitance,
which can disturb the transportation of the pressure wave, that
is the blood pressure intensity of the artery will decrease.
From the equationΔP(ω) = KB f , the blood flux may decrease also.

------------

第 38 筆
國家圖書館索書號: 系統編號: 86NTU00442181
     研究生: Lu胡志明 HU, CHI-MIN
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 肺音擷取系統及氣喘之哮鳴分析
    論文名稱: Lung sound recording system and analyzing of wheezing
    指導教授: 王唯工 Wei-Kong Wang
李茂煇 Maw H. Lee
吳惠東 Huey-Dong Wu
郭德盛 Te-Son Kuo
    學位類別: 碩士
    校院名稱: 國立台灣大學
    系所名稱: 電機工程學系
      學號: R84523127
     學年度: 86
     語文別: 中文
    論文頁數: 94
     關鍵字: 肺音 Lung sound
氣喘 Asthma
哮鳴 Wheezing
時頻分析 Time-frequency
transformations
聲譜圖 Sonogram
音框判斷法則 Frame decision rule
[摘要]
中文摘要
    氣喘病基本上是一種與呼吸道收縮有關的慢性支氣管發炎,乃是
一種臨床症候群。
氣喘主要症狀中,哮鳴是最典型的氣喘症狀。因此,以哮鳴作為氣喘監視器或警報器之
主要訊號來源乃是目前較可行的方式。
    本論文以商品化之麥克風,配合自製的濾波器、放大器與類比數
位轉換器,記錄肺
音訊號,並將其數位化輸入個人電腦中作離線儲存及分析。所記錄的資料,分別分析其
時域上與頻域上之特徵。並引入可包含時間因素的時-頻轉換方法,包括以快速傅立葉轉
換為基礎的短時間傅立葉轉換及以自迴歸法為基礎的分析方法。
    針對分析結果,我們選擇以聲譜圖方式顯示,其中以自迴歸法作
分析所得到的聲譜
圖效果最好。最後,我們使用自行開發的音框判斷法區分正常肺音與哮鳴現象,大量減
少所需要的運算量。
就區分正常肺音與哮鳴現象而言,本方法已經有初步可行的結果。本論文期望將來能夠
據此開發即時氣喘警報系統。並希望能以本論文為基礎,進一步針對其他不正常肺音作
進一步研究。
Abstract:
    Wheezing is the cardinal medical finding of asthma. A
new device for recording lung sound
    based on personal computer that is composed of a
microphone with stethoscope bell and
    preamplifier, a high pass filter, a low pass anti-
aliasing filter, and an ADC with a main amplifier
    and microprocessor for transmitting data is developed.


    Breathing sounds were recorded in normal and athmatic
patient over the trachea in the neck.
    The power spectra of the sounds were analyzed by FFT
based and AR based time-frequency
    transforms.


    Sonogram were used to present the results of analyzed
by time-frequency transform and
    the feature of wheezing is apparent, especially in the AR based one.


    We introduced the frame decision rule method to auto-
recognizing the wheezing signal pattern
    from normal lung sound. It has less data than digital
image processing and performance as well.


    We now can distinguish between normal lung sound and
wheezing successfully and the real-time
    monitoring and alarm system is expected. We try to
analyze other abnormal lung sound on
    the base we did as well.


Keywords: Lung sound, Asthma, Wheezing, FFT, AR modeling, Sonogram,
       Time-frequency transformations, Frame decision rule.
↑回到頂端↑
#415401 - 2004-09-09 15:50:09 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 30 筆
國家圖書館索書號: 系統編號: 88NTU00442015
     出版年: 民89
     研究生: 詹明宜 Ming-Yie Jan
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 動脈與微循環之血液動力學關聯性研究
    論文名稱: A Study of the Relationship between Marcohemodynamics and
Microhemodynamics
    指導教授: 王唯工 教授 Wei-Kung Wang, Ph.D.
    學位類別: 博士
    校院名稱: 國立臺灣大學
    系所名稱: 電機工程學研究所
      學號: D82503057
     學年度: 88
     語文別: 中文
    論文頁數: 77
     關鍵字: 血壓 blood pressure
血流 blood flow
高血壓 hypertension
血液動力學 hemodynamics
共振理論 resonance theory
氣血 Chi
雷射都卜勒血流計 Laser-Doppler blood
flowmeter
微循環 microcirculation
全文影像: (依著作權法相關規定,以下全文影像僅限國家圖書館館內下載)
封面
目錄
中文摘要
英文摘要
第一章 緒論
第二章 循環系統之血液動力學特性
第三章 近代血液動力學的回顧與徑向共振理論
第四章 動脈與微循環之血液動力學關聯性
第五章 脈動血壓波趨動微循環血流之效應及其高血壓之關聯
第六章 結論與未來方向
其他
[摘要]
根據根據世界衛生組織(World Health Organization, WHO)的報告,在已開發國家中,循
環系統疾病是最主要的死亡原因。在近代基礎循環力學的研究,大都以Navior-Stoke方程
式為基礎,從分析一小塊血液在主動脈的流動出發,研究循環系統中的血流。而動脈中的
血壓波則因為血液阻力及慣性而衰減;在主動脈中,當血壓波往下傳遞時,平均動脈血壓
值並沒有任何明顯的改變,但是血壓波的振幅卻明顯的增加。對此一現象,則認為是動脈
分枝及周邊循環阻抗會造成反射波疊加而成。如果血流的慣性力是循環系統中主要的作用
力,經過主動脈到周邊循環十幾階的分枝、網狀的微循環及反射波疊加,微循環中的血流
應該不是脈動的。
反之,從徑向共振理論出發,各個器官或動脈血管樹叢各有其共振頻率,經由長波長的動
脈血壓波藕合共振;藕合的動脈血壓波驅動在微循環中的血液流動。因此,微循環中的血
流應該是脈動的,且在同一器官或動脈血管樹叢中,微循環血流是同相的。
考慮血流的路徑,在循環系統中兩種型態與功能的極端關聯中:(1)血流量最大的腎臟皮質
表層微循環與腹主動脈血壓波,及(2)血流量最小的足部皮膚微循環與手橈動脈血壓波。以
雷射都普勒血流計量測微循環血流,並同步量測動脈血壓波。結果顯示,微循環中的血流
都是脈動的,而且同一組織內的微循環血流是同相的。這驗證了徑向共振理論與藕合共振
理論對體循環與微循環血液動力關聯性的推論。
研究中進一步探索脈動血壓波對末梢微循環的血流的驅動效率。研究中定義一微循環血流
及脈動血壓波面積比(Flux-to-Pressure-Area-Ratios, FPARs),以評估脈動血壓波中峰值
與較低血壓部分的效率差異。結果顯示脈動血壓之峰值是有較高的驅動效率的,且當血壓
波之脈動比(Blood Pressure Pulsatile Index, BPPI) 超過一定閾值時,脈動血壓波中峰
值的驅動效率會大幅增加。由此一結果推論,高血壓的成因可能是身體中的重要組織的周
邊血管組織變硬阻塞時,循環系統回饋調節以循環血流,因而大幅提升脈動血壓波的結果



[摘要]
According to the WHO report, in the developed countries, the circulatory
diseases are the main causes of death. In haemodynamic research, most
approaches based on the Navior-Stoke equation investigate the precise movement
of a small element of liquid in the artery. Meanwhile, both the viscous force
and inertial force would attenuate the blood pressure wave. However, the
pulsatile blood pressure is amplified from aorta to the downstream artery. The
strange phenomenon is regarded as by superposition of the reflected waves
generated by the vascular branches and the impedance of peripheral vascular
beds. If the flow does act the key role in the circulation, the peripheral
vascular fluxes, which have to flow through a complex network and be
interfered by the numerous reflected waves, would be constant and no phase
could be detected.
On the contrary, according to the radial resonance theory, each organ or
vascular bed has its own natural frequency; through the coupling by the long-
wavelength blood pressure, the peripheral vascular fluxe is driven by the
coupled blood pressure. Thus, it would be pulsatile and the fluxes in the same
vascular bed would be coherent.
In this study, refer to the blood pathway, there are two critical conditions
about the peripheral blood flux perfused by the arterial blood pressure.
First, the flux in the most perfused renal cortical surface relates to the
abdominal aortic blood pressure. Second, the flux in the skin of a foot
relates to the radial blood pressure. We used a laser Doppler flowmetry (LDF)
to measure the blood fluxes on different sites of the observed tissues and a
pressure transducer simultaneously measured the blood pressure waves. The
results show that the peripheral blood flux not only is pulsatile but also has
constant phase relation with arterial blood pressure; moreover, all blood
fluxes in the same tissue are coherent. It is coincident with the inference of
the radial resonance and the coupled resonance theory.
Furthermore, the driving efficience of the pulsatile blood pressure in renal
cortical surface was evaluated. We define a flux-to-pressure-area-ratio (FPAR)
to evaluate the efficiency that the pulsatile blood pressure drives the renal
cortical fluxe. The result shows that the higher the pulsatile blood pressure,
the more the driven flux is, and it seems that there is a threshold of blood
pressure pulsatile index (BPPI) that the driving efficiency would be amplified
abruptly. That implies the pulsatility plays a role in lowering the vessel
resistance of PVBs and it could also regulate the blood pressure in large
arteries. As a result, we further infer that if the precapillary openings are
obstructed or the peripheral blood vessels become stiffer the pulsatile
pressure will be induced to become higher so as to keep the blood perfusion
could be responsible for the hypertension.


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[8] Zweifach BW: Quantitative studies of microcirculatory structure and
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[9] Intaglietta M, Pawula RF and Tompkins WR: Pressure measurements in the
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Prentice Hall, 1988.

----------------

第 34 筆
國家圖書館索書號: 系統編號: 87NTU00442053
     研究生: 陳美全 Chen Mei-Chuan
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 與心跳同步微弱電刺激器之研製
    論文名稱: Heartbeat Synchronized Electrical Stimulator with Low
Stimulating Current
    指導教授: 王唯工 W.K. Wang
    學位類別: 碩士
    校院名稱: 國立臺灣大學
    系所名稱: 電機工程學研究所
      學號: R86921042
     學年度: 87
     語文別: 英文
    論文頁數: 41
     關鍵字: 乳酸 lactate
刺激器 stimulator
心電圖 ECG
R波 R wave
雷射都普勒血流計 LDF
[摘要]
現代人由於生活忙碌、緊張以及缺乏運動等因素,很多人年紀輕輕就有局部循環不良而酸
痛的問題,如肩膀酸痛、腰酸及下背痛等等,引起這些不適的原因很複雜,疼痛發生的機
制也還未為人所熟知。
一般而言,發生酸痛的部位通常都有局部缺氧的現象,也有人研究發現缺氧的組織中乳酸
分子的濃度與正常部位的濃度有所不同,所以局部乳酸濃度的變化應能反映出生理裡狀況
的異常,我們並認為乳酸的極性特性可能在生理上具有極大的意義,身體上多種電訊號如
心電圖、肌電圖等可利用這種特性疏通循環,本研究的重點是欲設計出與心電圖中R wave
同步的電刺激器,以做為心電圖R Wave 的增幅器,針對乳酸具有大dipole的特性,對局部
施予微弱的電刺激,期其能參與並輔助心電圖疏通循環的效果;為了觀察是否有疏通阻塞
、改善微循環之效果,吾人亦進行一組實驗,利用一組雷射都普勒血流計量取刺激局部的
血流訊號,以瞭解此種微弱電刺激對局部微循環的影響,我們並可由實驗結果看出此種與
心電圖中R waves同步的微弱電刺激器的確能有效的改善局部微循環,我們希望能以此研究
作為基礎,而在將來開發出有效改善微循環進而治療酸痛的醫療器材。


[摘要]
In modern life, low-back pain, neckaches and other kinds of pain have become
one of the most troubling problems. Pressure and busy lives make many young
persons have these problems. The real causes of these types of discomfort are
very complicated and not yet clear. The mechanisms of pains are also not
completely understood.
Generally, the spots of chronic pain or many other health problems often are
ischemic, and when somewhere in our bodies was in ischemia, the local
concentration of lactate changed. Therefore, the local change of the
concentration of lactate may associate with the physiological abnormality in
human. In other words, the concentration of lactate could be one kind of
indicators of some health problems. We also considered the characteristic of
large dipole of lactate is very important in physiology. As a result, the
electrical field from ECG or EMG, which is acting as the stepping potential,
can easily switch the blockage that causes the ischemia.
Our study is to implement the heartbeat synchronized electrical stimulator,
the stimulator we designed acts as an amplifier of the R waves in ECG. And we
use the LDF to conduct an experiment to observe the effects of the heartbeat
synchronized electrical stimulator on microcirculation. As the results of the
experiments, the effects of heartbeat synchronized electrical stimulator with
low stimulating current on microcirculation was evident. We hoped we could
develop a potent apparatus in the future.


[論文目次]
Chinese Abstract
English Abstract
Chapter 1 Introduction
1.1 Introduction
1.2 Motivation
1.3 Organization of the thesis
Chapter 2 Theory
2.1 Introduction to lactate
2.2 The study of a simple fluid composition analysis by electrode method
2.3 The study of the electro-dermal diagnostic system
2.4 Introduction to ECG
2.5 Electrodes
Chapter 3 Heartbeat Synchronized Electrical Stimulator Design
3.1 System overview
3.2 Pre-amplifier
3.3 60HZ notch filter
3.4 R wave detector
3.5 The other circuits
3.6 The results of measurement
Chapter 4 Experiment
4.1 Instruments
4.2 Subjects
4.3 Experimental protocol
4.4 Data analysis
4.5 Statistics
Chapter 5 Results
5.1 The effects of the heartbeat synchronized electrical stimulator on
microcirculation
5.2 Statistics
Chapter 6 Conclusions
6.1 The implementation of the circuit designs
6.2 The effects of the heartbeat synchronized electrical stimulator on
microcirculation
6.3 Conclusions
Bibliography


[參考文獻]
[1] Richard A, Deyo, " Low-Back Pain", Scientific American, August 1998, pp.
28-33.
[2] Jay B. Brodsky, and James B. D. Mark, " Postthoracoscopy Pain: Is TENS the
Answer", Ann Thorac Surg 63, 1997, pp. 608-610.
[3] Deirdre M. Walsh, Andrea S. Lowe, Kenneth McCormack, Jean-Claude Willer,
G. David Baxter, and Jim M. Allen, " Transcutaneous Electrical Nerve
Stimulation: Effect on Peripheral Nerve Conduction, Mechanical Pain Threshold,
and Tactile Threshold in Humans", Arch Phys Med Rehabil, vol 79, September
1998, pp. 1051-1058.
[4] Wayne W. Fisher, Lynn G. Bowman, Rachel H. Thompson, and Stephanie A.
Contrucci, " Reductions in Self-Injury Produced by Transcutaneous Electrical
Nerve Stimulation", Journal of Applied Behavior Analysis, 31, 1998, pp. 493-
496.
[5] Walsh DM, " TENS: Clinical Applications and Related Theory", Edinburgh
Churchill Livingstone, 1997.
[6] Lei Chen, Jun Tang, Paul F. White, Alexander Sloninsky, Ronald H. Wender,
Robert Naruse, and Robert Kariger, " The Effect of Location of Transcutaneous
Electrical Nerve Stimulation on Postoperative Opioid Analgesic Requirement:
Acupoint Versus Nonacupoint Stimulation", Anesth Analg, 87, 1998, pp. 1129-
1134.
[7] Melzack R, Wall PD, " Pain Mechanisms: A New Theory", Science, 150, 1965,
pp. 971-979.
[8] Richard Ohrbach and Elliot N. Gale, " Pressure Pain Thresholds in Normal
Muscles: Reliability, Measurement Effects, and Topographic Differences", Pain,
37, 1989, pp. 257-263.
[9] G. C. Wang, H. Hsiu, Y. Chiang and Y. Y. Lin Wang, " A Simple Fluid
Composition Analysis by Electrode Method", Submitted to IEEE transaction of
Biomrdical Engineering.
[10] John G. Webster, " Medical Instrumentation", John Wiley & Sons, Inc.
[11] W, K, Wang, H. Hsiu, Y. Chiang, G. C. Wang, and Y. Y. Lin Wang, " The
Measurement of the Electro-Dermal Diagnostic System".
[12] Campbell, " Biochemistry", 3rd edition, Saunders College.
[13] Eva Hagstorm-Toft, Staffan Enoksson, Erik Moberg, Jan Bolinder, and Peter
Arner, " Absolute Concentrations of Glycerol and Lactate in Human Skeletal
Muscle, Adipose Tissue, and Blood", The American Physiological Society, 1997,
pp. 584-592.
[14] Wills J. Tompkins, " Biomedical Digital Signal Processing - C-Language
Examples and Laboratory Experiments for the IBM PC", Prentice-Hall.
[15] Jules Conatant, " Learning Electrocardiography", Little, Brown Company (
Inc.).
[16] Rosell, J. J. Colominas, P. Pallas-Areny, and J. G. Webster, " Skin
Impedance from 1Hz to 1 MHz", IEEE Trans. Biomed. Eng. 35, 1998, pp. 649-651.
[17] E. J. Woo, P. Hua, J. G. Webster, W. J. Tompkins, R. Pallas-Areny, " Skin
Impedance Measurements Using Simple and Compound Electrodes", Med. & Biol.
Eng. & Comput, 30, 1992, pp. 97-102.
[18] W. K. Wang, T. L. Hsu, H. C. Chang and Y. Y. Lin Wang, " Effect of
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23 (2), 1995, pp. 121-130.
[19] V. S. Letokhov, " Laser Biology and Medicine", Nature 316, 1985, pp. 325-
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[23]實用經穴學,陳怡魁編著
↑回到頂端↑
#415402 - 2004-09-09 15:51:23 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 27 筆
國家圖書館索書號: 系統編號: 89NTU00442021
     出版年: 民90
     研究生: 許昕 Hsin Hsiu
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    電子全文: 電子全文下載
    論文名稱: 動脈系統藉共振機制傳遞血壓波之研究
    論文名稱: A study of the Resonance Mechanism on the Arterial Blood
Pressure Wave Transmission
    指導教授: 王唯工
    學位類別: 博士
    校院名稱: 國立臺灣大學
    系所名稱: 電機工程學研究所
      學號: D84523029
     學年度: 89
     語文別: 中文
    論文頁數: 103
     關鍵字: 血壓 blood pressure
共振 resonance
動脈硬化 arterial stiffness
聲波 sound wave
血液流體力學 hemodynamic
動脈 artery
高血壓 hypertension
氣功 chigong
全文影像: (依著作權法相關規定,以下全文影像僅限國家圖書館館內下載)
封面
目次
第一章緒論
第二章理論推導與比較
第三章橫拉主動脈對血壓波之影響¾動脈硬化生理意義之探討
第四章低頻共振聲波對循環運作之影響
4-1 波源設計與先遣實驗
4-2 與心跳速率同步之低頻聲波對心率變異率的影響
4-3 利用與心跳速率同步之低頻聲波來控制心跳速率
4-4 以二倍頻共振聲波
第五章結論與未來展望
參考資料
[摘要]
長期以來,循環系統疾病在已開發國家,一直是重要的死因。這代表現代科學對循環系統
雖然投入大量研究資源,但瞭解仍嫌不足,而無法對循環疾病的治療與預防產生助益。
   現代循環理論是把動脈視為血液流動的管道,進而衍生出診斷、藥物、保健等種種醫
療產業。但在實際生理中,心臟僅用1.7瓦的輸出功率,來面對動脈系統的的繁複結構,克
服血液流經管壁的龐大阻力,並將血液推送至全身每一個角落。若把動脈當作血液流動的
管道,這種輸送效率是無法達成的。在我們的想法中,這也就是現代研究無法對循環系統
運作徹底瞭解的關鍵原因。
   由於在主動脈的機械能量分配中,由管壁振動儲存的彈性位能佔了98%,遠超過血液
本身流動的2%,因此共振理論把動脈視為血壓波的傳遞系統:心臟將血液打出,撞擊在主
動脈弓的彎曲上,以增大血壓脈波的振幅;此血壓脈波經動脈傳遞至末端後,再藉由末端
血管床的小開口(opening),將血液推送至微血管網,完成供血的任務;各器官(或血管床
)則藉由與心跳的良好共振,以大幅提昇動脈系統血壓波的傳輸效率。由此概念,循環系
統的高輸送效率才能得到解釋。
   在本研究中,我們從兩個角度來探討共振機制對動脈傳遞血壓波的影響:
一 橫拉主動脈實驗
   由共振理論,由於動脈硬化會使血管彈性特性改變,破壞器官與心跳間的良好共振,
使血壓波傳遞效率降低,進而造成血壓的下降,這與目前高血壓理論的推論不同。在實驗
中,我們以橫拉主動脈模擬實際生理中的動脈硬化,以釐清此一爭議。
二 低頻共振聲波實驗
   由共振理論,主動脈與各器官(或血管床)各自依其彈性特性,具有不同的共振頻率
,利用此一共振特性,各器官就好比機械式的天線(antenna),能有效率地接收由心臟送來
的血壓波。若我們由外界經適當介質,送入與心跳速率相近或其整數倍頻的振動聲波,同
樣由於上述共振特性,聲波的能量也有可能被動脈或器官吸收,進而影響循環系統的運作
。此一現象必須在”把動脈系統視為波傳遞系統”的前提下,才有可能獲得解釋。
   在橫拉主動脈實驗中,我們觀察到血壓下降,同時由共振理論的數學模式,也可良好
預測其波形變化。而在低頻共振聲波實驗中,我們已可藉由心跳速率一倍及二倍頻率的振
動聲波,來控制大白鼠的心跳速率,並增大某特定諧波之振幅。這些成果對共振理論循環
系統架構的想法:(1)動脈系統為壓力波的傳遞系統 (2)共振機制協助提昇動脈壓力波的傳
遞效率,都提供了強有力的證據。


[摘要]
Circulatory diseases have long been main causes of mortality in developed
countries. It implies that although much effort in modern research was focused
on circulatory physiology, the understanding was so little that it does not
contribute much to the prevention of circulatory diseases.
   In most hemodynamic theories, the artery is treated as pathway of blood
flow. However the heart has an output power of only 1.7 Watt in vivo. It is
hard to believe that with this small power, as well as the heart faces the
large resistance of the arterial system, it can still distribute the blood to
the whole body. It impresses us with its high transmission efficiency.
   Since the elastic potential energy occupies more than 98% of mechanical
energy in the aorta, which is much larger than the 2% of the kinetic energy of
flowing blood, the resonance theory treats the arterial system as a pressure-
wave-transmitting one. The heart pushes the blood into the aorta, and the
blood collides on the vessel wall of the ascending aorta arch to generate
pulse pressure. This pulse pressure is transmitted to the microcirculatory
region along the artery, and pushes the blood into the capillary network
through small openings of the arteriole. The organic vascular beds resonate
with the heartbeat to further improve the transmission efficiency of the
pressure wave.
   In this study, we discuss the effect of the resonance mechanism to the
arterial transmission from two aspects:
1. Aorta bending experiment - a simulation on arterial stiffening
   From the resonance theory, arterial stiffness will alter the elastic
property of the aortic wall, and hence destroy the coupled resonance between
the organic vascular beds and the heartbeat. It will decrease the arterial
transmission efficiency for the pressure wave, thus lower the blood pressure.
It is an opposite inference to modern theories in hypertension. We pulled the
aorta transversely to simulate the arterial stiffness in vivo to observe the
changes of the blood pressure.
2. Effects of sound wave synchronized with the heartbeat on circulatory
regulation
   From the resonance theory, the aorta and organic vascular beds own their
resonance frequencies respectively according to their elastic properties. Just
like a mechanical antenna, a vascular bed can efficiently receive pressure
wave coming from the heart. Similarly, if we send external sound wave with
frequency near the heart rate or its multiple frequency, its energy may be
absorbed by the arterial system, hence affect the hemodynamics.
   In the former experiment, we observed the drop of the blood pressure, and
we can use the mathematical model of the resonance theory to predict the
alteration of the pressure waveform. In the latter experiment, we can use the
sound wave with frequency of the heart rate and its double frequency to steer
the heart rate of the rats. We can also increase the amplitude of some
harmonics in this way.
These results provide strong supports to the resonance theory that the
arterial system is a pressure-wave transmitting one, and that the resonance
mechanism help improve this transmission efficiency.


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5. Yu GL, Wang Lin YY, Wang WK. Resonance in the kidney system of rats. Am. J.
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6. Young ST, Wang WK, Chang LS, Kao TS. Specific frequency properties of the
renal and the supermesenteric arterial beds in rats. Cardiovas. Res. 1989; 23:
465-467.
7. Young ST, Wang WK, Chang LS, Kao TS. The filter properties of the arterial
beds of organs in rats. Acta. Physiol. Scand. 1992; 145: 401-406.
8. Wang Lin YY, Chang CC, Chen JC, Hsiu H, Wang WK. Pressure wave propagation
in arteries. IEEE Eng. Med. Biol. 1997; 16: 51-56.
9. Wang Lin YY, Lia WC, Hsiu H, Jan MY, Wang WK. Effect of length on the
fundamental resonance frequency of arterial models having radial dilatation.
IEEE T Bio.-Med. Eng.2000; 47: 313-318.
10. Hsiu H, Jan MY, Wang Lin YY, Wang WK. Effects of aorta bending and renal
ligation on the blood pressure: a simulation on arterial stiffening. IEEE Eng.
Med. Biol., in review.
11. Hsiu H, Jan MY, Wang Lin YY, Wang WK. Effects of weak external mechanical
force stimulation on the heart rate variability of rats. Am. J. Chin. Med. In
Review.
12. Hsiu H, Jan MY, Wang Lin YY, Wang WK. Influencing the heart rate of rats
with weak external mechanical stimulation. PACE, in revision.
13. Hsiu H, Luo KJ, Wang Lin YY, Wang WK. Semi-empirical resonance equations
for the artery with organs. Biomedical Engineering-Applications, Basis &
Communications 2000; 12(2): 12-20.
14. Jan MY, Hsiu H, Hsu TL, Wang Lin YY, Wang WK. The importance of the
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2000; 19(3): 106-111.
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37. O’Rourke MF, Kelly RP. Wave reflection in the systemic circulation and
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38. Bassingthwaighte JB, Liebovitch LS, West BJ. Fractal Physiology. New York:
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39. Sopher SM, Camm AJ. Atrial fibrillation: maintenance of sinus rhythm
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40. Hondeghem LM. Classification of antiarrhythmic agents and the two laws of
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41. Jalife J, Antzelevitch C. Phase resetting and annihilation of pacemaker
activity in cardiac tissue. Science 1979; 206: 695-697.
42. Guevara MR, Glass L, Shrier A. Phase locking, period-doubling bifurcations,
and irregular dynamics in periodically stimulated cardiac cells. Science 1981;
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43. Garfinkel A, Spano ML, Ditto WL, Weiss JN. Controlling cardiac chaos.
Science 1992; 257: 1230-1235.
44. Poon CS, Merrill CK. Decrease of cardiac chaos in congestive heart
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Stanley HE. Multifractory in human heartbeat dynamics. Nature 1999; 399: 461-
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join in? Aust. NZ. J. Med. 1993; 23: 708-710.
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48. Andren L, Gindstedt G, Bjorkman M, Borg KO, Hansson L. Effect of noise on
blood pressure and ‘stress’ hormones. Clin. Sci. 1982; 62(2): 137-141.
49. Beckers F, Ramaekers D, Aubert AE, Cleemput van J, Droogne W, Vanhaecke J,
Ector H, Van de Werf F. Evolution of intracardiac heart rate variability of
the native sinus node in heart transplant patients. Medical & Biological
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50. Lanuza DM, Grady K, Hetfleisch M, Johnson MR. Circadian rhythm changes in
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--------------

第 28 筆
國家圖書館索書號: 系統編號: 89NTU00442187
     出版年: 民90
     研究生: 姜智昂 Chiang Chi-Ang
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    電子全文: 電子全文下載
    論文名稱: 動脈系統之頻率匹配
    論文名稱: The Frequency Matching rule in Arterial system
    指導教授: 王唯工 Wang Wei-Kong
    學位類別: 碩士
    校院名稱: 國立臺灣大學
    系所名稱: 電機工程學研究所
      學號: R88921150
     學年度: 89
     語文別: 中文
    論文頁數: 80
     關鍵字: 動脈系統 arterial
共振 resonance
徑向 radial
匹配 match
血壓波 pressure wave
諧波 harmonic
頻譜 spectrum
頻率 frequency
[摘要]
本研究以「徑向共振理論」為主軸,將生理解剖上出現的一些動脈管的結構,利用彈性管
來進行模擬。探討的對象包括不同材質管子的相接,以模擬動脈管不均質中,最簡化的狀
況。動脈一分為二,因這是動脈系統上最常見的分支結構。另有出現在四肢及頭部的環狀
結構,以及討論發展到n階的血管叢及不規則的血管形態。並配合上實驗的量測,以及應用
「徑向共振理論」來做的理論估測,在比較下顯示這理論的適用性。
接續上段之研究,若是再配合上生理上心臟端的訊號源,因它是呈現穩定的週期運動,故
可知道整個動脈系統的強度頻譜,在發生峰值的頻率應該要具有諧波的關係,才能夠在最
有效率的情況下使用心臟所供給的能量。從這樣的想法出發,並以「徑向共振理論」推導
這頻率匹配的條件。
最後再以生理上觀察到動脈血壓波的分布,以一些模擬上的條件來達成從動脈端過度到微
循環的方式。以及分別改變分支環(代替血管叢)和分支管,來了解主動脈接上分支動脈叢
時能量及頻率的再分配。


[摘要]
This research applies the Radial Resonance Theory to variety of the arterial
structures that would appear in the human's circulation  This research
applies the Radial Resonance Theory to variety of the arterial structures that
would appear in the human's circulation system.
 Then we use some kinds of elastic tubes to simulate the above structures
verifying the capability of the Radial Resonance Theory. First, for the non-
uniform property of the artery, we reduce the complexity by connect just two
different kinds of tubes together. Next, the most obvious way the arteries
generate is the one to two branches (bifurcation). We simulate this by
different length and boundary condition. Third, the loop-like artery
structures which appear in the legs, arms and the head. Also the N generation
artery structure and the asymmetric one would be discussed.
  On the other hand, we know that the heart pumps the blood in an almost
periodically way. Thus the energy that heart support for the whole circulation
system would be in harmonic frequency in the view of signals. In order to have
the highest efficiency, we deduce that the spectrum of the artery system would
have a 'frequency matching "relationship with the source. This rule can also
be derived from the Radial Resonance Theory.
At last, we simulate the artery to the microcirculation by a simple way to
give an explanation for the physiological phenomenon. And the experiment that
control the branch circle and branch tube length to show the relationship
among the energy redistribution and frequency splitting.


[論文目次]
第一章    緒論
第二章    理論模型探討
2-1   前人研究相關模型
2-1-A  Hales;"Windkessel"Model
2-1-B  Poiseuill's equation
2-1-C  Moens-Korteweg equation
2-1-D  Navier-Stokes equation
2-1-E  類比電路模型
2-2  Womersley equation
2-3  共振理論
2-3-A 開端及演進
2-3-B 彈性管波動方程式推導
2-3-C 流量與壓力關係
第三章    實驗設備及步驟
3-1 實驗設備
3-2實驗方法與裝置
3-3 校正工作
第四章    不同分支管結構
4-1 兩段厚薄不同彈性管之連接
4-2 一分為二之結構
4-3環狀結構
4-4 任意二階型及不規則型分支探討
第五章    頻率匹配
5-1脈衝響應解和匹配條件
5-2 值的計算及其和 之關係
  5-2-A  值的計算
  5-2-B  和 之關係
5-3 實驗結果驗證
5-3-A 兩段不同材質相串
5-3-B  三段不同材質串聯
5-3-C  三段不同材質並聯
第六章    動脈到微循環&分支環
第七章    討論與結論
附錄A 血液循環常用觀念及術語
  附錄B 文獻回顧
  參考文獻


[參考文獻]
[1]Milnor W.R:Hemodynamics(2nd ed) WILLIAMS&WILKINS.(1989)
[2]McDonald.D.A .1974: Blood flow in arteries. 2nd edn.London:Edward Arnold
[3]Hamilton.W.F.and Dow.P.1939:An experimental study of the standing waves in
the pulse propagated through the aorta. American Journal of Physiology 125.48-
59
[4] Noodergraaf.A.Circulatory system Dynamics.Academic Press N.Y.(1978)
[5]Yu GL.Wang Lin YY and Wang WK:Resonance in the kidney system of rats.Am.J.
Physiol.267:H1544-8.1994
[6]Vascular dynamics : physiological perspectives / edited by N. Westerhof and
D.R. Gross New York : Plenum Press. c1989
[7]黃啟裕:主動脈血壓波與血流波的模擬與分析.國立台灣大學物理研究所.碩士論文.1998
[8]賴文哲:主動脈振動與天然頻率之探討. 國立台灣師範大學物理研究所.碩士論文.1996
[9]許昕:共振理論於長直管中流體行為之探討. 國立台灣大學電機研究所.碩士論文.1995
[10]陳忠誠:壓力波在血管中行進的模擬與探討. 國立台灣師範大學物理研究所.碩士論文.
1994
[11]羅熀哲:分支動脈叢間耦合作用之函數探討. 國立台灣師範大學物理研究所.碩士論文.
1994
[12]詹明宜:共振對血壓波之模擬.國立陽明醫學院醫學工程研究所.碩士論文1992
[13]徐清秀:彈性血管壓力波動方程式之初步應用. 國立台灣師範大學物理研究所.碩士論
文.2000
[14]張超群: 國立台灣師範大學物理研究所.碩士論文.1991
[15]Wang.W.K.Wang Lin.Y.Y.Hsu.T.L.and Ching. Y.:Some foundation of Pulse
feeling in Chinese Medicine.Advance in Bismedical Engineering Hemisphoen.
Washington.D.C p269-296(1989)
[16]Yuh-Ying Lin.C.C.Chiang.J.C.Chen.H.Hsiu.W.K.Wang :Pressure Wave Propagation
in a distensible tube arterial model .IEEE Engineering in Med.boil.Mag.pp51-56.
Jan1997.
[18]Shadwick RE.Goslin JM.Arterial mechanics in the fin whale suggest a unique
hemodynamic design.Am J Physiol. 1994 Sep;267(3 Pt 2):R805-18.
[19]Patel D.J..Janicki J.S..and Carew T.E:Static anitropic elastic properties
of the aorta in living dogs. Circ.Res.25:765-9.1969
[20]Burattini R. Gnudi G Computer identification of models for the arterial
tree input impedance:comparison between two new simple models and first
experimental results. Med Biol Eng Comput 1982 Mar;20(2):134-44
[21]Burattini R. Gnudi G Assessment of a parametric identification procedure
of simple models for left ventricular afterload. Med Biol Eng Comput 1983 Jan;
21(1):39-46
[22]Burattini R. Gnudi G. Westerhof N. Fioretti S Total systemic arterial
compliance and aortic characteristic impedance in the dog as a function of
pressure: a model based study.Comput Biomed Res 1987 Apr;20(2):154-65
[23]Burattini R. Di Carlo S Effective length of the arterial circulation
determined in the dog by aid of a model of the systemic input impedance.IEEE
Trans Biomed Eng 1988 Jan;35(1):53-61
[24]Burattini R. Campbell KB Modified asymmetric T-tube model to infer
arterial wave reflection at the aortic root.IEEE Trans Biomed Eng 1989 Aug;36(
8):805-14
[25]Campbell KB. Burattini R. Bell DL. Kirkpatrick RD. Knowlen GG Time-domain
formulation of asymmetric T-tube model of arterial system. Am J Physiol 1990
Jun;258(6 Pt 2):H1761-74
[26]Burattini R. Knowlen GG. Campbell KB Two arterial effective reflecting
sites may appear as one to the heart.Circ Res 1991 Jan;68(1):85-99
[27]Burattini R. Campbell KB Effective distributed compliance of the canine
descending aorta estimated by modified T-tube model.Am J Physiol 1993 Jun;264(
6 Pt 2):H1977-87
[28] Fogliardi R. Di Donfrancesco M. Burattini R Comparison of linear and
nonlinear formulations of the three-element windkessel model. Am J Physiol
1996 Dec;271(6 Pt 2):H2661-8
[29] Avolio AP. O'rourke MF. Mang K. Bason PT. Gow BS A comparative study of
pulsatile arterial hemodynamics in rabbits and guinea pigs .Am J Physiol 1976
Apr;230(4):868-75
[30]O'Rourke MF. Avolio AP Pulsatile flow and pressure in human systemic
arteries. Studies in man and in a multibranched model of the human systemic
arterial tree. Circ Res 1980 Mar;46(3):363-72
[31]Avolio AP. O'Rourke MF. Bulliman BT. Webster ME. Mang K Systemic arterial
hemodynamics in the diamond python Morelia spilotes. Am J Physiol 1982 Sep;243(
3):R205-12
[32]Avolio AP. Chen SG. Wang RP. Zhang CL. Li MF. O'Rourke MF Effects of aging
on changing arterial compliance and left ventricular load in a northern
Chinese urban community. Circulation 1983 Jul;68(1):50-8
[33]Nichols WW. Avolio AP. O'Rourke MF Ascending aortic impedance patterns in
the kangaroo: their explanation and relation to pressure waveforms. Circ Res
1986 Sep;59(3):247-55
[34] Nichols WW. O'Rourke MF. Avolio AP. Yaginuma T. Pepine CJ. Conti CR
Ventricular/vascular interaction in patients with mild systemic hypertension
and normal peripheral resistance. Circulation 1986 Sep;74(3):455-62
[35]Karamanoglu M. Gallagher DE. Avolio AP. O'Rourke MF Pressure wave
propagation in a multibranched model of the human upper limb. Am J Physiol
1995 Oct;269(4 Pt 2):H1363-9
[36]Hunter W. Noordergraaf A Can impedance characterize the heart? J Appl
Physiol 1976 Feb;40(2):250-2
[37]Li JK. Melbin J. Riffle RA. Noordergraaf A Pulse wave propagation.Circ Res
1981 Aug;49(2):442-52
[38]Campbell KB. Rhode EA. Cox RH. Hunter WC. Noordergraaf A Am J Functional
consequences of expanded aortic bulb: a model study. Physiol 1981 Mar;240(3):
R200-10
[39]Li JK. Melbin J. Noordergraaf A Directional disparity of pulse reflection
in the dog.Am J Physiol 1984 Jul;247(1 Pt 2):H95-9
[40] Campbell KB. Lee LC. Frasch HF. Noordergraaf A Pulse reflection sites
and effective length of the arterial system. Am J Physiol 1989 Jun;256(6 Pt 2):
H1684-9
[41]Laskey WK. Parker HG. Ferrari VA. Kussmaul WG. Noordergraaf A Estimation
of total systemic arterial compliance in humans.
J Appl Physiol 1990 Jul;69(1):112-9
[42]Li JK. Noordergraaf A Similar pressure pulse propagation and reflection
characteristics in aortas of mammals. Am J Physiol 1991 Sep;261(3 Pt 2):R519-21
[43]Berger DS. Li JK. Laskey WK. Noordergraaf A Repeated reflection of waves
in the systemic arterial system. Am J Physiol 1993 Jan;264(1 Pt 2):H269-81
[44]Frasch HF. Kresh JY. Noordergraaf A Wave transmission and input impedance
of a model of skeletal muscle microvasculature. Ann Biomed Eng 1994 Jan-Feb;22(
1):45-57
[45]Berger DS. Li JK. Noordergraaf A Differential effects of wave reflections
and peripheral resistance on aortic blood pressure: a model-based study.
Am J Physiol 1994 Apr;266(4 Pt 2):H1626-42
[46]Berger DS. Li JK. Noordergraaf A Arterial wave propagation phenomena.
ventricular work. and power dissipation. Ann Biomed Eng 1995 Nov-Dec;23(6):804-
11
[47]Stergiopulos N. Young DF. Rogge TR Computer simulation of arterial flow
with applications to arterial and aortic
stenoses.J Biomech 1992 Dec;25(12):1477-88
[48]Stergiopulos N. Tardy Y. Meister JJ Nonlinear separation of forward and
backward running waves in elastic conduits.
J Biomech 1993 Feb;26(2):201-9
[49]Stergiopulos N. Meister JJ. Westerhof N Simple and accurate way for
estimating total and segmental arterial compliance: the pulse pressure method.
Ann Biomed Eng 1994 Jul-Aug;22(4):392-7
[50]Stergiopulos N. Meister JJ. Westerhof N Evaluation of methods for
estimation of total arterial compliance.Am J Physiol 1995 Apr;268(4 Pt 2):
H1540-8
[51]Stergiopulos N. Meister JJ. Westerhof N Scatter in input impedance
spectrum may result from the elastic nonlinearity of the arterial wall.Am J
Physiol 1995 Oct;269(4 Pt 2):H1490-5
[52] Stergiopulos N. Meister JJ. Westerhof N Determinants of stroke volume
and systolic and diastolic aortic pressure.Am J Physiol 1996 Jun;270(6 Pt 2):
H2050-9
[53]Pythoud F. Stergiopulos N. Westerhof N. Meister JJ Method for determining
distribution of reflection sites in the arterial system.Am J Physiol 1996 Nov;
271(5 Pt 2):H1807-13
[54] Stergiopulos N. Westerhof BE. Westerhof N Physical basis of pressure
transfer from periphery to aorta: a model-based study.Am J Physiol 1998 Apr;
274(4 Pt 2):H1386-92
[55]Stergiopulos N. Segers P. Westerhof N Use of pulse pressure method for
estimating total arterial compliance in vivo.Am J Physiol 1999 Feb;276(2 Pt 2):
H424-8
[56] Stergiopulos N. Westerhof BE. Westerhof N Total arterial inertance as
the fourth element of the windkessel model. Am J Physiol 1999 Jan;276(1 Pt 2):
H81-8
[57]Latham RD. Westerhof N. Sipkema P. Rubal BJ. Reuderink P. Murgo JP 
Regional wave travel and reflections along the human aorta: a study with six
simultaneous micromanometric pressures.Circulation 1985 Dec;72(6):1257-69
[58]Latham RD. Rubal BJ. Westerhof N. Sipkema P. Walsh RA Nonhuman primate
model for regional wave travel and reflections along aortas. Am J Physiol 1987
Aug;253(2 Pt 2):H299-306
[59] Latham RD. Rubal BJ. Sipkema P. Westerhof N. Virmani R. Robinowitz M.
Walsh RA. Ventricular/vascular coupling and regional arterial dynamics in the
chronically
hypertensive baboon: correlation with cardiovascular structural adaptation.
Circ Res 1988 Oct;63(4):798-811
[1]Milnor W.R:Hemodynamics(2nd ed) WILLIAMS&WILKINS.(1989)
[2]McDonald.D.A .1974: Blood flow in arteries. 2nd edn.London:Edward Arnold
[3]Hamilton.W.F.and Dow.P.1939:An experimental study of the standing waves in
the pulse propagated through the aorta. American Journal of Physiology 125.48-
59
[4] Noodergraaf.A.Circulatory system Dynamics.Academic Press N.Y.(1978)
[5]Yu GL.Wang Lin YY and Wang WK:Resonance in the kidney system of rats.Am.J.
Physiol.267:H1544-8.1994
[6]Vascular dynamics : physiological perspectives / edited by N. Westerhof and
D.R. Gross New York : Plenum Press. c1989
[7]黃啟裕:主動脈血壓波與血流波的模擬與分析.國立台灣大學物理研究所.碩士論文.1998
[8]賴文哲:主動脈振動與天然頻率之探討. 國立台灣師範大學物理研究所.碩士論文.1996
[9]許昕:共振理論於長直管中流體行為之探討. 國立台灣大學電機研究所.碩士論文.1995
[10]陳忠誠:壓力波在血管中行進的模擬與探討. 國立台灣師範大學物理研究所.碩士論文.
1994
[11]羅熀哲:分支動脈叢間耦合作用之函數探討. 國立台灣師範大學物理研究所.碩士論文.
1994
[12]詹明宜:共振對血壓波之模擬.國立陽明醫學院醫學工程研究所.碩士論文1992
[13]徐清秀:彈性血管壓力波動方程式之初步應用. 國立台灣師範大學物理研究所.碩士論
文.2000
[14]張超群: 國立台灣師範大學物理研究所.碩士論文.1991
[15]Wang.W.K.Wang Lin.Y.Y.Hsu.T.L.and Ching. Y.:Some foundation of Pulse
feeling in Chinese Medicine.Advance in Bismedical Engineering Hemisphoen.
Washington.D.C p269-296(1989)
[16]Yuh-Ying Lin.C.C.Chiang.J.C.Chen.H.Hsiu.W.K.Wang :Pressure Wave Propagation
in a distensible tube arterial model .IEEE Engineering in Med.boil.Mag.pp51-56.
Jan1997.
[18]Shadwick RE.Goslin JM.Arterial mechanics in the fin whale suggest a unique
hemodynamic design.Am J Physiol. 1994 Sep;267(3 Pt 2):R805-18.
[19]Patel D.J..Janicki J.S..and Carew T.E:Static anitropic elastic properties
of the aorta in living dogs. Circ.Res.25:765-9.1969
[20]Burattini R. Gnudi G Computer identification of models for the arterial
tree input impedance:comparison between two new simple models and first
experimental results. Med Biol Eng Comput 1982 Mar;20(2):134-44
[21]Burattini R. Gnudi G Assessment of a parametric identification procedure
of simple models for left ventricular afterload. Med Biol Eng Comput 1983 Jan;
21(1):39-46
[22]Burattini R. Gnudi G. Westerhof N. Fioretti S Total systemic arterial
compliance and aortic characteristic impedance in the dog as a function of
pressure: a model based study.Comput Biomed Res 1987 Apr;20(2):154-65
[23]Burattini R. Di Carlo S Effective length of the arterial circulation
determined in the dog by aid of a model of the systemic input impedance.IEEE
Trans Biomed Eng 1988 Jan;35(1):53-61
[24]Burattini R. Campbell KB Modified asymmetric T-tube model to infer
arterial wave reflection at the aortic root.IEEE Trans Biomed Eng 1989 Aug;36(
8):805-14
[25]Campbell KB. Burattini R. Bell DL. Kirkpatrick RD. Knowlen GG Time-domain
formulation of asymmetric T-tube model of arterial system. Am J Physiol 1990
Jun;258(6 Pt 2):H1761-74
[26]Burattini R. Knowlen GG. Campbell KB Two arterial effective reflecting
sites may appear as one to the heart.Circ Res 1991 Jan;68(1):85-99
[27]Burattini R. Campbell KB Effective distributed compliance of the canine
descending aorta estimated by modified T-tube model.Am J Physiol 1993 Jun;264(
6 Pt 2):H1977-87
[28] Fogliardi R. Di Donfrancesco M. Burattini R Comparison of linear and
nonlinear formulations of the three-element windkessel model. Am J Physiol
1996 Dec;271(6 Pt 2):H2661-8
[29] Avolio AP. O'rourke MF. Mang K. Bason PT. Gow BS A comparative study of
pulsatile arterial hemodynamics in rabbits and guinea pigs .Am J Physiol 1976
Apr;230(4):868-75
[30]O'Rourke MF. Avolio AP Pulsatile flow and pressure in human systemic
arteries. Studies in man and in a multibranched model of the human systemic
arterial tree. Circ Res 1980 Mar;46(3):363-72
[31]Avolio AP. O'Rourke MF. Bulliman BT. Webster ME. Mang K Systemic arterial
hemodynamics in the diamond python Morelia spilotes. Am J Physiol 1982 Sep;243(
3):R205-12
[32]Avolio AP. Chen SG. Wang RP. Zhang CL. Li MF. O'Rourke MF Effects of aging
on changing arterial compliance and left ventricular load in a northern
Chinese urban community. Circulation 1983 Jul;68(1):50-8
[33]Nichols WW. Avolio AP. O'Rourke MF Ascending aortic impedance patterns in
the kangaroo: their explanation and relation to pressure waveforms. Circ Res
1986 Sep;59(3):247-55
[34] Nichols WW. O'Rourke MF. Avolio AP. Yaginuma T. Pepine CJ. Conti CR
Ventricular/vascular interaction in patients with mild systemic hypertension
and normal peripheral resistance. Circulation 1986 Sep;74(3):455-62
[35]Karamanoglu M. Gallagher DE. Avolio AP. O'Rourke MF Pressure wave
propagation in a multibranched model of the human upper limb. Am J Physiol
1995 Oct;269(4 Pt 2):H1363-9
[36]Hunter W. Noordergraaf A Can impedance characterize the heart? J Appl
Physiol 1976 Feb;40(2):250-2
[37]Li JK. Melbin J. Riffle RA. Noordergraaf A Pulse wave propagation.Circ Res
1981 Aug;49(2):442-52
[38]Campbell KB. Rhode EA. Cox RH. Hunter WC. Noordergraaf A Am J Functional
consequences of expanded aortic bulb: a model study. Physiol 1981 Mar;240(3):
R200-10
[39]Li JK. Melbin J. Noordergraaf A Directional disparity of pulse reflection
in the dog.Am J Physiol 1984 Jul;247(1 Pt 2):H95-9
[40] Campbell KB. Lee LC. Frasch HF. Noordergraaf A Pulse reflection sites
and effective length of the arterial system. Am J Physiol 1989 Jun;256(6 Pt 2):
H1684-9
[41]Laskey WK. Parker HG. Ferrari VA. Kussmaul WG. Noordergraaf A Estimation
of total systemic arterial compliance in humans.
J Appl Physiol 1990 Jul;69(1):112-9
[42]Li JK. Noordergraaf A Similar pressure pulse propagation and reflection
characteristics in aortas of mammals. Am J Physiol 1991 Sep;261(3 Pt 2):R519-21
[43]Berger DS. Li JK. Laskey WK. Noordergraaf A Repeated reflection of waves
in the systemic arterial system. Am J Physiol 1993 Jan;264(1 Pt 2):H269-81
[44]Frasch HF. Kresh JY. Noordergraaf A Wave transmission and input impedance
of a model of skeletal muscle microvasculature. Ann Biomed Eng 1994 Jan-Feb;22(
1):45-57
[45]Berger DS. Li JK. Noordergraaf A Differential effects of wave reflections
and peripheral resistance on aortic blood pressure: a model-based study.
Am J Physiol 1994 Apr;266(4 Pt 2):H1626-42
[46]Berger DS. Li JK. Noordergraaf A Arterial wave propagation phenomena.
ventricular work. and power dissipation. Ann Biomed Eng 1995 Nov-Dec;23(6):804-
11
[47]Stergiopulos N. Young DF. Rogge TR Computer simulation of arterial flow
with applications to arterial and aortic
stenoses.J Biomech 1992 Dec;25(12):1477-88
[48]Stergiopulos N. Tardy Y. Meister JJ Nonlinear separation of forward and
backward running waves in elastic conduits.
J Biomech 1993 Feb;26(2):201-9
[49]Stergiopulos N. Meister JJ. Westerhof N Simple and accurate way for
estimating total and segmental arterial compliance: the pulse pressure method.
Ann Biomed Eng 1994 Jul-Aug;22(4):392-7
[50]Stergiopulos N. Meister JJ. Westerhof N Evaluation of methods for
estimation of total arterial compliance.Am J Physiol 1995 Apr;268(4 Pt 2):
H1540-8
[51]Stergiopulos N. Meister JJ. Westerhof N Scatter in input impedance
spectrum may result from the elastic nonlinearity of the arterial wall.Am J
Physiol 1995 Oct;269(4 Pt 2):H1490-5
[52] Stergiopulos N. Meister JJ. Westerhof N Determinants of stroke volume
and systolic and diastolic aortic pressure.Am J Physiol 1996 Jun;270(6 Pt 2):
H2050-9
[53]Pythoud F. Stergiopulos N. Westerhof N. Meister JJ Method for determining
distribution of reflection sites in the arterial system.Am J Physiol 1996 Nov;
271(5 Pt 2):H1807-13
[54] Stergiopulos N. Westerhof BE. Westerhof N Physical basis of pressure
transfer from periphery to aorta: a model-based study.Am J Physiol 1998 Apr;
274(4 Pt 2):H1386-92
[55]Stergiopulos N. Segers P. Westerhof N Use of pulse pressure method for
estimating total arterial compliance in vivo.Am J Physiol 1999 Feb;276(2 Pt 2):
H424-8
[56] Stergiopulos N. Westerhof BE. Westerhof N Total arterial inertance as
the fourth element of the windkessel model. Am J Physiol 1999 Jan;276(1 Pt 2):
H81-8
[57]Latham RD. Westerhof N. Sipkema P. Rubal BJ. Reuderink P. Murgo JP 
Regional wave travel and reflections along the human aorta: a study with six
simultaneous micromanometric pressures.Circulation 1985 Dec;72(6):1257-69
[58]Latham RD. Rubal BJ. Westerhof N. Sipkema P. Walsh RA Nonhuman primate
model for regional wave travel and reflections along aortas. Am J Physiol 1987
Aug;253(2 Pt 2):H299-306
[59] Latham RD. Rubal BJ. Sipkema P. Westerhof N. Virmani R. Robinowitz M.
Walsh RA. Ventricular/vascular coupling and regional arterial dynamics in the
chronically
hypertensive baboon: correlation with cardiovascular structural adaptation.
Circ Res 1988 Oct;63(4):798-811
t;63(4):798-811
↑回到頂端↑
#415403 - 2004-09-09 15:52:25 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 20 筆
國家圖書館索書號: 系統編號: 91NTU00442035
     出版年: 民92
     研究生: 郭士揚 Alex KOU
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    電子全文: 電子全文下載
    論文名稱: 新穎性診斷醫療器材驗證之基準 -- 以非侵入式血糖量測系統為例
    論文名稱: The Fundamental for Novel Diagnostic Device Certification
- One Blood Glucose Monitoring System as an Example
    指導教授: 王唯工 Wei Kung WANG
    學位類別: 碩士
    校院名稱: 國立臺灣大學
    系所名稱: 電機工程學研究所
      學號: P89921017
     學年度: 91
     語文別: 英文
    論文頁數: 73
     關鍵字: 新穎性診斷醫療器材 Novel Diagnostic Device
驗證 Certification
血糖 Blood Glucose
風險管理 Risk Managemrent
衛生署 Department of Health
藥政處 Bureau of Pharmaceutical
Affairs
審查員 Reviewer
損益分析 Risk/Benefit Analysis
[摘要]
近年來,國內醫學工程學術界發表許多新創性的生理量測方法的論文研究,倘若進一步商
品化成為新穎性診斷醫療器材,必然需要經過安全性與功效驗證程序,符合國家衛生主管
機關-行政院衛生署所訂頒的醫療器材相關法規命令之要求。所以在新穎性診斷醫療器材
設計開發之先,先就研究的實驗結果,彙編整成產品開發計畫書,向衛生署生技服務窗口
申請晤談。產品研究開發者在申請前,需要對當前全球調和化的驗證基準要項,及早預作
充分的準備,對產品的新穎性介紹給衛生署醫療器材審查員,充足的客觀證據答覆審查員
所關切的問題,提供審查員高信賴水準的解答。政府的立場,基於把關保護人民安全用藥
原則外,相當鼓勵學術界將新穎性的生理量測方法研究成果產品功效化,提升國人的生活
品質;就由學、官雙方直接意見溝通,可以降低開發成本、節省摸索的時間,相對地可以
盡快搶得上市商機。新穎性診斷醫療器材驗證之基準,對不同的適應症與核心量測技術,
就具有不同的術語詮釋之,爲使本論文所提的驗證基準要項易於明瞭與應用,特別
選擇王唯工教授新設計開發一非侵入式血糖量測系統Tangtest為範例,有助其他類同的新
穎性診斷醫療器材設計開發計畫書之編撰,迅速有效地引導凝聚學、官雙方對談的共識。
本研究主題主要動機係發掘出新穎性診斷醫療器材產品化的前端諮商活動要項與流程途徑
,研究結果衍生出三個研究成效:
- 經由早期學、官雙方溝通方法的建立,讓醫療器材審查員認識新穎性的生理量測技術,
同時學界開發者能明瞭藥事法與醫療法對新醫療器材與新診斷技術的法規命令之要求,俾
使研究開發之產品品質與上市許可審查過程順暢,避免新穎性診斷醫療器材上市前查驗登
記申請案遭到衛生署多次剔退,徒然浪費雙方的時間與經費。
- 研提新穎性診斷醫療器材之審查的品質系統運作,藉以提升產品設計開發審查程序的品
質與效益。
- 提供當前最新的適應症與新技術應用指引,據以建置展開新產品開發活動。
期望政府未來能持續訂頒行政指導,俾利學、官雙方就標準作業程序有所遵循,共同努力
推展生醫科學的應用暨降低風險的技術開發。迅速有效地幫助學術界產品開發者設計製造
出新醫療器材、以及進行臨床試驗,尤其是現今學界研究經費與健保給付均相當緊縮的情
況下,亟需要幫助將學術界的新發明在侷限的資源下,能夠順利開發出新產品,也間接降
低了病患醫療照護的支出。


[摘要]
This thesis was motivated to design and develop a model for novel diagnostic
device certification to enhance product safety and effectiveness. It
represented the global harmonization’s current thinking on the fundamental of
this model providing developers’ reference with the novel diagnostic device
targeted science needed to ask the right questions early. It was a broad
initiative to make innovative medical diagnostic technologies available
sooner, and to reduce the costs of developing a safe, effective and novel
diagnostic device while maintaining Department of Health's traditional high
standards of consumer protection. It included an example for one blood glucose
monitoring system as an alternative approach might be used if such approach
satisfies the DOH requirements of the applicable statute and regulations in
order to identify key scientific questions early in total product life cycle
for new technologies. It was intended to achieve this study motivation through
new actions in three major areas:
- Reducing the delays and avoidable product development costs by avoiding
multiple cycles of DOH review when possible, through early communication and
other steps to improve the quality of a novel diagnostic medical device
applications;
- Improving the quality and efficiency of the review process, by adopting a
quality systems approach to novel diagnostic medical device reviews;
- Facilitating new product development, by providing clearer up-to-date
guidance for particular diseases and for emerging technologies.
 The initiative sought to establish regulatory standards and processes that
reflect the latest biomedical and risk management science. Improved
communication and guidance could help medical device developers achieve
improvements by helping them design their clinical studies more effectively.
Savings could be used by the sponsor to develop other innovations, and passed
on to patients as lower product and service prices.


[論文目次]
The Fundamental for Novel Diagnostic Device Certification
-One Blood Glucose Monitoring System as an Example
               Contents
中文摘要
Abstract
I. Introduction
II. Organizational Elements
III. Valid Scientific Evidence
IV. Summary of Safety and Effectiveness
V. Labeling
VI. Device Characteristics and Manufacturing
VII. Non-clinical Laboratory Studies
VIII. Clinical Investigations
IX. PDP for One Blood Glucose Monitoring System
X. Discussion
XI. Conclusion
References


[參考文獻]
1. FDA, Fiscal Year 2002 Annual Report of ODE, 2003-01-08
2. FDA, 21 CFR 812.3(k), Revised as of April 1, 2002
3. FDA News for Immediate Release P03-49, FDA Clears New Diabetes Device for
Marketing, Media Inquiries: 301-827-6242, Consumer Inquiries: 888-INFO-FDA,
July 7, 2003.
4. NCCLS Approved Guideline. GP10-A Assessment of the Clinical Accuracy of
Laboratory Tests Using Receiver Operating Characteristic (ROC) Plots. NCCLS,
940 West Valley Road, Suite 1400, Wayne, PA 19087.
5. FDA Blue Book Memo #91.1
6. FDA’s Internet site at
http://www.fda.gov/cdrh/fedregin.html
7. Sharon Snider, FDA T96-66, Standards for New Medical Devices, ANSWERS 10/4/
1996

-------------

第 24 筆
國家圖書館索書號: 系統編號: 90NTU00442026
     出版年: 民91
     研究生: 翁三偉
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    電子全文: 電子全文下載
    論文名稱: 微光偵測器的設計
    指導教授: 王唯工
    學位類別: 碩士
    校院名稱: 國立臺灣大學
    系所名稱: 電機工程學研究所
      學號: P88921014
     學年度: 90
     語文別: 中文
     關鍵字: 光感測器 Photodetector
非侵入性 Non-Invasive
[摘要]
光在經過人體時,由於不同的組織對不同波長的光有著不同的吸收及散射作用。利用此一
特點,可以光來檢測生理上的一些指標。且低功率的光線對人體的傷害可以降到最低。
光在經過人體組織的吸收及散射作用後,能夠被外界偵測的有效光相對低了許多,因此設
計一個能夠偵測低有效光的光放大器是必要的。


[論文目次]
第一章 緒論
第二章 理論背景
第三章 微光偵測器系統規格
第四章 系統硬體之設計
第五章 結果
第六章 討論
參考文獻 31


[參考文獻]
[1] Y.D.Lin, C.D. Tsai, H.H. Huang, D.C. Chiou, and C.P. Wu “ Preamplifier
with a Second-Order High-Pass Filtering Characteristic,”,
IEEE Trans. Biomed. Eng., Vol. 46, pp. 609-612, 1999.
[2] G.E. Tobey, “Operational amplifiers design and Applications,” pp. 303-
308, McGraw Hill, 1971.
[3] F-S. Jaw, “Optimal sampling of electrophysiological signals,” Neurosci.
Res. commun. Vol.28, pp. 75-84, 2001.
[4] “Wiley encyclopedia of electrical and electronics engineering,” Vol.1 by
Webster, John G., 1999.
[5] U.Tietze and Ch.Schenk,“Electronic circuits,”pp. 503-511, 1990.
[6] Mark I. Montrose, “EMC and the printed circuit board : design, theory,
and layout made simple,”pp.13-14, IEEE Press, 1999.
[7]HENRY W.OTT, “Noise reduction techniques in electronic systems,” pp.253-
254, Wiley-interscience 1976.

---------

第 22 筆
國家圖書館索書號: 系統編號: 90NCKU5442091
     出版年: 民2002/06/27
     研究生: 林宏益 Hung-Yi Lin
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    電子全文: 電子全文下載
    論文名稱: 脈波/回音式超音波器官微共振量測系統
    論文名稱: A Pulse-Echo Ultrasonic System for Measuring Micro-
Vibration of Organ in Resonance
    指導教授: 楊明興 M.S. Young
    學位類別: 碩士
    校院名稱: 國立成功大學
    系所名稱: 電機工程學系碩博士班
     學年度: 90
     語文別: 中文
    論文頁數: 74
     關鍵字: 微共振 Micro_vibration
新型相位差演算法 CPLD
超音波 Ultrasonic
CPLD New phase difference
algorithm
[摘要]
共振是自然界的一種現象,代表能量的轉移時的一種狀態;以電路學的串聯諧振而言,當
所有的電抗性都互相抵銷時,整體的電路阻抗最小,所以流入的電流會最大;由王唯工教
授和林玉英教授所提出的器官血管叢共振理論可以得知人體的器官也有異曲同工之妙,因
為把器官看成一個埠(Port),而血管就是線路,所以推論上就會有類比於電路共振的器官
共振頻率存在,如果知道這些共振頻率,就可以依照這些頻率的強度可分佈來觀看人體各
器官的健康情況,以期達到預防保健的目的。
而我這一篇論文旨在發展一種量測方法用來量測這種共振頻率,而這種頻率的特徵是以心
臟為基頻及其諧波所組成,我們取到十倍諧波,所以頻率的範圍從1.2Hz到10Hz左右,且振
動的位移極小;在模擬器官振動的實驗時,我們建構一個水下低頻微振動系統,以超音波
為傳感器用來感測振動信號,因為超音波可以穿透皮膚表體的軟組織和組織液,並
以Altera公司所出的CPLD 來做數位信號的處理,因為CPLD可以工作於高頻(在本論文中是
使用100MHz當基頻),再把計數的資料送到89C51做新型相位差演算法計算;在初期實驗,
我們以沈水式超音波做直接侵入量測,從實驗的結果可知,本系統可以量測到和模擬器官
的振動相近之頻率,所以期望未來能有更突破性的發展,完全利用超音波的優點,將其擴
展到非壞壞性侵入量測。


[摘要]
Resonance is a phenomenon of physics, it is a state of transformation that
energy can transfer into port with maximum power. According to electric
circuit theory, reactance are cancel  each other and total impedance keep
real resistor, have some analogy with human body. By Wang W.K and Lin Y.Y, “
the Resonance Effect on Blood Pressure and Flow hypothesis”, there have
resonant frequency in vitals.
  Our study is to develop a measurement system for detecting resonant
frequency. These resonance frequency have a characteristic from 1.2Hz to 10Hz,
it have a low frequency and small displacement. In our approach, we construct
a underwater model that imitate vitals. We use ultrasonic transducer to detect
vibrate signal and count by CPLD, then transmit the count data to 89C51. In
89C51, we built in the new phase difference algorithm and show the result by
PC. By experiment result, we have a good estimation for simulated organ micro-
vibration frequency.


[論文目次]
目 錄
中文摘要 I
英文摘要 II
目錄   III
圖表目錄     V
第一章緒論 1
1.1 前言 1
1.2研究動機與目的               4
1.2.1 超音波和雷射的差別 4
1.3 前人研究 6
1.2.1 超音波脈波/回音法 6
1.2.2 超音波相位差法 11
1.4本實驗室研究成果   15
  1.4.1 新型相位差法             15
1.4.2 脈波/回音法與相位差法的比較 18
第二章研究方法 19
2.1 研究方法     19
2.2 系統方塊 23
第三章系統設計 25
3.1 類比信號流 25
3.2 數位信號流 33
3.2.1 相位差計數 33
3.2.2 Delay_1的清除與中斷觸發 38
3.3 軟體設計 42
3.3.1相位差演算程式設計 42
3.3.2顯示程式設計   46
第四章系統測試 48
4.1 振動模擬系統的建立 48
4.2 實驗方法與結果 49
4.2.1 相位計的輸出與示波器的波形比較 49
第五章討論 51
5.1 雜訊改進與缺點分析 52
第六章結論 57
6.1 本論文的貢獻  57
6.2 論文結果自評               58
6.3 未來的研究方向 60
參考文獻   61
附錄一整體電路圖 63
附錄二ALTERA數位信號流電路圖       65
附錄三89C51演算法程式 67
附錄四模擬系統(OCL)電路 70
附錄五系統實體電路 71
自述
後記


[參考文獻]
[1] Feynman, Leighton, Sands, “Lectures on physics”, volume I, chapter 4
Addison - wesley publishing 1963. [2] 李良修,”走過帕金森幽谷:李良修與疾病搏
鬥、成長的生命記錄”,天下文化,1999. [3] C.W Lin, “A New Design of the
Electromagnetic Sensor for Measuring the Absolute Displacement”, Master
dissertation of National Cheng Kung Univ. 1997. [4] S.C Liao, “The Simulation
of the Resonance Effect on Blood Pressure and Flow”, Master dissertation of
National Taiwan Univ. 1992. [5] Y.C Li, “Design and Implementation of
Automatic Measurement Methods for Animal Behavior”, Doctoral dissertation of
National Cheng Kung Univ. 1992 [6] www.Altera.com [7] www.Atmel.com [8] tefan
Koi, “Ultrasonic Measurements and Technologies”, Pp.64-76, Chapman & Hall,
UK, 1996. □S□c□s [9] Y.P Hwang, “Application of Contaminants Sensing and
Capturing Techniques to Range Hood during Home Cooking”, Master dissertation
of National Cheng Kung Univ. 2000. [10] Robert A.W, “Electronic Test
Instruments”, Pp.167-169 Prentice Hall 1993. [11] K. Ikeda, “Ultrasonic
Measurement of Sound Velocity in Liquids which Automatically Eliminates
Temperature Dependence”, IEEE Conference on Ultrasonic Symposium 1998. [12]
tefan Koi, “Ultrasonic Measurements and Technologies”, Pp.63-66, Chapman &
Hall, UK, 1996. □S□c□s [13] Dan H. Wolaver, “Phase-locked loop circuit
design”, Prentice Hall,1991. [14] Oliver B. M, Jean P. Remenieras, “
Noncontact Measurement of Vibration Using Airborne Ultrasound”, IEEE., Trans.
Ultrason., Ferroelect., Freq., Contr.vol.45,No.3,May1998. [15] Daniele
Marioli, Claudio Narduzzi. “Digital Time-of-Flight Measurement for Ultrasonic
Sensors”, IEEE., Trans. Instrum Meas., vol.41,No.1,Feb 1992. [16] Andria
Nemat, “A Digital Frequency Independent Phase Meter”, IEEE. Trans. Instrum
Meas., vol.39, No.4, Aug 1990. [17] Syed Masud Mahmud, Andrzej Rusek, “A
Microprocessor-Based Dual Slope Phase Meter”, IEEE. Trans. Instrum Meas., vol.
37,No.3,Sept 1988. [18] M.S Young, Y.C. Li, “A High Precision Ultrasonic
System for Vibration Measurements”, Rev. Sci. Instrum. 63(11) Nov 1992. [19]
C.W. Young, M.S Young, C.W. Young, M.T. Lin, “A New Ultrasonic Method for
Measuring Minute Motion Activities on Rat”, J. Neurosci Methods 1996;70:45-
49. [20] M.S Young, C.W. Young, Y.C. Li, ”A Combined System for Measuring
Animal Motion Activities”, J. Neurosci. Methods 2000;95:55-63. [21] Francis
E. Gueuning, Mihai Varlan, “Accurate Distance Measurement by an Autonomous
Ultrasonic System Combining Time-of-Flight and Phase-Shift Methods”, IEEE
Trans. Instrum Meas., vol.46, No.6, Dec 1997. [22] Kuo En Hsu, “A Study of
Combined Measurement Techniques for Animal’s Locomotor and Vibratory
Behaviors ”, Master dissertation of National Cheng Kung Univ. 2002.
↑回到頂端↑
#415404 - 2004-09-09 15:53:30 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 15 筆
國家圖書館索書號: 系統編號: 91NCKU5442168
     出版年: 民2003/07/31
     研究生: 賴瑞揚 Juei-Yang Lai
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 末梢血流波形之動態即時量測與分析系統之設計
    論文名稱: Design of Real-Time System for Dynamically Measuring and
Analyzing the Peripheral Blood Flow Waveform
    指導教授: 楊明興 Ming-Shing Young
    學位類別: 碩士
    校院名稱: 國立成功大學
    系所名稱: 電機工程學系碩博士班
     學年度: 91
     語文別: 中文
    論文頁數: 58
     關鍵字: 末梢血流波形 peripheral blood flow
waveform
諧波分析 harmonic wave analysis
[摘要]
 中國醫學遠在現代西方醫學興起前,便開始有其自成一套的診斷及治療結構,更是幾千
年來中國人智慧的結晶,照顧著世世代代中國人的健康,並成為中國文化的寶典。近年來
,中央研究院王唯工教授所提出的氣血循環共振理論,認為近代十大死因中大多與循環有
關,主因大部份都是由於循環不良所造成的,而血循環可以說是身體統治每一個器官及組
織所使用的工具,其包含供給身體各個細胞與組織所需的養分,及用來對抗病菌所需的進
攻物質。
 本論文研製一個末梢血流波形即時量測與分析系統,量測身體血循環末稍血流波形變化
,即時記錄及分析,以利血流波形資料能加以量化及統計分析,找出血循環與生理狀況之
相互關係,作為研判參考之用。此外,本系統與壓力感測器量測橈動脈血壓波形之量測及
分析系統,作相互比較,證明本系統之可行性。


[摘要]
 Chinese Medicine was innovated earlier than Modern Medicine. It is a bible
of Chinese civilization in medicine. Chinese Medicine originated from Chinese
people’s intelligence. And it has taken care of Chinese health generation by
generation for thousands years.
 Recently, a resonance model of blood pressure circulation was presented by
professor W.K. Wang. He considers that top ten of diseased death is related to
blood circulation and the main cause is obstructive in blood circulation.
 This study develops a system with the function of real-time measuring,
recording and analyzing the variation of peripheral blood flow waveform. The
result is used to estimate the relation between blood circulation and
physiological condition. It can be offer a reference for a medical doctor.


[論文目次]
 中文摘要                        Ⅰ
 英文摘要Ⅱ
 致謝Ⅲ
 目錄Ⅳ
 表目錄Ⅶ
 圖目錄Ⅷ
 第一章 緒論1
 1-1研究動機1
 1-2研究目的2
 第二章 系統設計原理與方法4
 2-1 系統架構4
 2-2 硬體設計6
 2-2-1 光感測器6
 2-2-2 量測電路模組設計8
 2-2-3 類比至數位轉換電路設計12
 2-2-4 串列傳輸介面電路設計15
 2-2-5 系統電源供應電路模組設計16
 2-3 韌體設計  20
 2-4 軟體設計21
 2-4-1 通訊介面程式22
 2-4-2 訊號取樣頻率23
 2-4-3 分析處理程式24
 2-4-3-1 消除基線漂移25
 2-4-3-2 擷取特徵週期26
 2-4-3-3 諧波分析28
 2-4-3-4 統計分析29
 第三章 系統功能測試與整合30
 3-1 系統功能測試31
 3-2 量測電路模組測試32
 3-3 類比至數位轉換電路測試32
 3-4 串列傳輸介面電路測試32
 3-5 系統電源電路模組測試32
 3-6 系統整合測試33
 第四章 實驗方法與結果34
 4-1 實驗方法及設備34
 4-2 實驗結果35
 4-2-1 十位正常男子分析結果35
 4-2-2 病人分析結果41
 第五章 討論  44
 第六章 結論46
 參考文獻48
 附錄
 附錄AAT89C51單晶片微處理器韌體程式51
 附錄B系統電路圖53
 附錄C 諧波成分與臟器經絡的關係表57
 自述 58


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-----------------

第 19 筆
國家圖書館索書號: 系統編號: 91NTU00198008
     出版年: 民92
     研究生: 鮑建國 BAU, Jian-Guo
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    電子全文: 電子全文下載
    論文名稱: 穴診機制與量化之研究
    論文名稱: Study of Mechanism and Quantification of Acu-scope
    指導教授: 王唯工 WANG, Wei-Kung
陳義裕
    學位類別: 博士
    校院名稱: 國立臺灣大學
    系所名稱: 物理學研究所
      學號: D83202010
     學年度: 91
     語文別: 中文
    論文頁數: 80
     關鍵字: 穴診儀 Acu-scope
電極 electrode
極化 polarization
酸鹼度 pH
電阻抗 impedance
瞬態 transient
缺氧 ischemia
伏爾電針 EAV
[摘要]
近年來,對於疾病的病因探討與治療的方法主要集中在基因的研究上,然而,當組織細胞
無法獲得足夠的供血,會立刻反應在細胞功能的下降,長期則會造成結構性的改變甚至死
亡。穴診與脈診法即是從循環生理學的角度出發,希望經由及早診斷因血液循環系統的障
礙而處於缺氧狀態下的組織,以提供及早治療的依據。1980年代王唯工博士提出動脈血壓
波的共振理論,並由共振理論建立脈診法,脈診法是經由分析動脈血壓波波形以獲得全身
供血分配的診斷方法。我們希望進一步建立可量測局部組織在現有供血下的功能表現的診
斷方法。以EAV (Electro-Acupuncture according to Dr. Voll) 為主的穴診法是以量測
體表特定位置(通常是穴道點)的電阻抗的診斷方法。本論文的研究目的即是在由脈診
與EAV系統的研究經驗出發,為穴診法建立自物理學到生理學的理論基礎與量化的方法。
第二章共振理論與脈診,運用生物檢測(bio-assay)的想法,以活體大白鼠研究入脾經藥物
的藥效。如同共振理論的預測,八種入脾藥的效果對血壓波的第三諧波振幅百分比有顯著
的增加。此結果一方面可為中藥藥物的藥理找到現代生理學的理論基礎,一方面也在次驗
證依循共振理論建立的脈診法有效性。第三章中,在仔細檢討EAV系統的操作過程與包括兩
個電極在內的量測系統後,我們改將量測電極扎入皮下,並以程式控制的開關來提供穩定
的極化電壓,至此完成第一階段的系統標準化與結果的量化的工作。由和脈診及病人自覺
症狀的比較,顯示改良後的穴診系統不但與EAV系統有一致的診斷結果,更可達到可重現性
的量測。第四章我們在模擬系統上進行穴診儀原理的初探。當增加量測電極附近乳酸─無
氧醣解作用的產物的濃度時,極化電流顯示出較高的峰值,這與EAV在病態時量測的結果一
致。但是由反覆的校正實驗中發現,量測電極以外的部位對量測亦有貢獻。因此,為提昇
穴診系統的解析度與診斷能力,第五章與第六章分別定量分析被測系統(生物體)與量測
電極對量測的影響。在第五章對受測體進行整體分析,我們分別評估 (A) 大面積接觸電極
之阻抗,(B) 與電極接觸部分之皮膚阻抗,(C) 身體內部迴路之阻抗,對量測結果的貢獻
,並定量計算出各部分的阻抗值。由等效電路獲得的第一階近似顯示,當量測電極愈小,
愈可經由電容效應的分析量測到局部組織的阻抗變化,而瞬態電流的峰值則仍然同時受(B)
、(C)兩部分的影響而並非局部的效應。第六章中單獨研究量測電極的貢獻。在對模擬系統
中含不同濃度乳酸的NaCl溶液的量測結果顯示,乳酸濃度的升高主要反應在極化電容的增
加,所以當量測電極夠小,局部乳酸變化造成的局部電容改變可不受身體其他部分干擾,
而由電流曲線下面積得到。第七章我們針對穴診信號的來源:電極介面的極化進行研究,
我們發現對電極極化之瞬態電流(transient response)貢獻最大的因素是pH的變化,而
在缺氧的生理條件下組織的pH會因為乳酸的堆積而下降,這表示我們所建立的缺氧指標應
該是缺氧狀態下組織的pH改變所造成。
透過定量量測與分析的方法,穴診與脈診是了解中國傳統醫學的科學化工具。結合現代醫
學的工具與知識,與中醫學對整體氣血循環的認識,未來穴診法可以配合脈診法做為篩檢
與診斷循環生理運作正常與否方便而有效的工具。此外也可進一步開發成可微小化、幾乎
無傷害的組織pH的量測方法。


[摘要]
In 1980’s, a resonance theory was developed to describe the behavior of the
pulse for the blood pressure wave. Based on the resonance theory, pulse
analysis was built to obtain the information of the energy distribution in the
whole body. On the other hand, as a company of the pulse analysis, an
integrated diagnosis, a method for the functional diagnosis of specific tissue
is still needed. EAV (Electro-Acupuncture according to Dr. Voll), a widespread
method was used in Homeopathy to diagnose “energy” by measuring the skin
impedance of specific acupuncture points. Based on previous clinical and
fundamental studies of the pulse analysis and EAV, I aim at building the
working principles from physics to physiology and developing the quantitative
analysis of Acu-scope for the “local” diagnosis.
In chapter two, “resonance theory and pulse analysis”, the idea of bio-assay
is applied to study the effect of eight herbs used in Chinese medicine. As the
prediction of the resonance theory, all eight spleen-meridian-related herbs
increase the third harmonic proportion of blood pressure wave significantly.
The results not only provide pharmacological foundation for Chinese herbs, but
also give further supports for the efficiency of the resonance theory and the
pulse analysis. In chapter three, we standardize and quantify EAV by applying
subcutaneous measuring electrodes and using a programmable switch. The
modified Acu-scope system performs the same results in diagnosis and
especially shows highly reproducible ability. In chapter four, we investigate
the mechanism of Acu-scope in phantom. When the concentration of lactate is
increased near the measuring electrode, the peak current of polarization
becomes larger. Although the results are consistent with that of EAV, the
deviated calibration data seem still revealing the influence beyond the
interface of the measuring electrode. In order to enhance the performance of
the Acu-scope, we study the contributions of each part of samples and the
measuring electrodes respectively in chapter five and six. In chapter five,
contributions of three parts are evaluated: (A) interface impedance of surface
electrodes, (B) skin impedance contacted with surface electrode, and (C)
impedance of inner part of body. In the first order approximation of the
equivalent circuit, part (A) can be ignored, part (B) and (C) vary for
different subjects and should be taken into account. If the size of the
measuring electrode is small enough, total capacitance effect of the
polarization is determined by the capacitance of polarization at the measuring
electrode interface. Therefore, it can be used as a sensor to detect the
specific spot. Opposite to the capacitance effect, the peak current of
transient is influenced by both of the part (B) and (C). In chapter six, the
contribution of the measuring electrode is studied in particular. The enhanced
concentration of lactate mainly increases the capacitance of the polarization
rather than the peak current. In chapter seven, the influence of KCl on
polarization is compared with that of HCl. We observe that the electrode
polarization is mainly effected by pH. Because the pH decrease follows the
increase of the lactate in ischemia tissue, it reveals the measured signal of
the Acu-scope should be due to the variation of the pH in ischemia tissues.
By the quantitatively analytic methods, Acu-scope and the pulse analysis are
the scientific tools to investigate the traditional Chinese medicine.
Cooperated with the modern medicine and the experience of traditional
medicine, the Acu-scope can be coordinated with the pulse analysis to develop
as the screening and diagnostic device for the investigation on the severity
of ischemia tissues. With the advantages of a minimized electrode and short
response time, the Acu-scope will also be practical for either in-vitro or in-
vivo pH measurement.


[論文目次]
第一章 缺氧診斷-未來預防醫學的新方向           1
第二章 共振理論與脈診                   7
第三章 穴診儀的標準化與量化               21
第四章 穴診儀的原理初探與定量校正            35
第五章 穴診儀整體分析與改良               41
第六章 量測電極與穴診儀的量測              63
第七章 電極極化與pH量測                 69
第八章 結論與未來工作                  79
參考資料                         81


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↑回到頂端↑
#415405 - 2004-09-09 15:54:18 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 9 筆
國家圖書館索書號: 系統編號: 91CMCH0050014
     出版年: 民92
     研究生: 蔡嘉一 Chia I Tsai
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    電子全文: 電子全文下載
    論文名稱: 以清醒大鼠急性失血模型之動脈壓分析探討中醫亡血證之藏象反應
    論文名稱: Arterial Blood Pressure Analysis onViscera-state
Following Acute Bleedingin Conscious Rat
    指導教授: 蘇奕彰 Yi Chang Su
林昭庚
李采娟
    學位類別: 碩士
    校院名稱: 中國醫藥學院
    系所名稱: 中國醫學研究所
     學年度: 91
     語文別: 中文
    論文頁數: 70
     關鍵字: 急性失血 Acute bleeding
藏象系統 Viscera-state
快速傅立葉轉換 Fast Fourier transformation
頻譜分析 Frequency analysis
[摘要]
大量急性失血在急症醫學上是常見的,在機體失血時,會引起許多生理上的代償反應,這
些都會造成血壓波時域以及頻域上的變化。中醫傳統理論認為人體由藏象系統負責協調質
量與能量的分佈與利用,因此當減少了運行於脈管中之營血之後,相關氣血路徑以及代償
反應所導致的之能量分布或波動規律應當有所變化,這是在以往典籍文獻中或現代相關研
究較少提及的。因此本研究嘗試藉由頸動脈處之動脈壓諧波頻譜分析,觀察急性失血所導
致的亡血證對藏象系統之影響。
實驗方式是將體重250-350公克的雄性Spargue-Dawley 大鼠,以乙醚(ether)麻醉後埋管
,清醒後分別從左股動脈放血,並從右頸動脈紀錄血壓波。從實驗開始全程紀錄老鼠的動
脈收縮壓、動脈舒張壓、平均動脈壓、脈搏壓,並將老鼠在放血過程中各階段的血壓波以
快速傅立葉轉換作頻譜分析,並以ANOVA以及t -test作統計分析。
結果發現,放血對於C0值(心氣)的確有降低之效果。而存活組之心氣值約在距離第一次
放血完成9-10分鐘顯著上升,可能與C1值(肝氣)在放血後0-1分鐘顯著上升有關。對於死
亡組而言,肝氣也可被「營血脫失」之效應所引發,只是引發之速度較晚,約在5-6分鐘之
間;C2 值(腎氣)可與肝氣一同被「營血脫失」之效應所引發,而且其速度可能比肝氣稍
快一些。這個結果印證,中醫失血後之生理應激反應主要是透過肝與腎兩個藏象來進行。


[摘要]
Acute bleeding in emergency medicine is not unusual. It could result in many
compensatory responses, including the activation of sympathetic system, the
inhibition of parasympathetic system, and the activation of hormone system.
Traditional Chinese medicine theory indicates that Viscera-state controls the
utility and redistribution of energy and material. When the blood in the
vessel is lost, the route of Qi and blood and the principle of undulation
should be shifted consequently. But the consequence of the activation of
Viscera-state has not clearly been described in the past study. The purpose of
this study is to investigate the response of the Viscera-state to the loss of
blood by the analysis of arterial blood pressure.
Left femoral arterial blood pressure was measured using the blood pressure
transducer, and right carotid artery pressure was recorded in term of the
following parameters: systolic pressure, diastolic pressure, mean arterial
pressure, and the pulse pressure. The arterial blood pressure was analyzed
with Fast Fourier transformation and different stages of blood pressure were
compared. The results were analyzed with ANOVA and t-test.
If the rats survived for 21 minutes after secondary bleeding, they were
defined group 1. If they did not survived, they were defined group 2. The
results demonstrate that the heart Qi value (C1) of group 1 was significantly
increased in 9-10 minutes after first bleeding. It may be induced by the
significant increase of the liver Qi value (C0) in 0-1 minutes after first
bleeding. The liver Qi of group 2 was also induced at 5-6 minutes after
bleeding. The kidney Qi (C2)of group 2 was also induced, but is faster.
These are consistent with the stress response in Chinese medicine theory is
relative with the activation of liver and kidney Qi.


[論文目次]
目錄
第一章 前言 1
第二章 文獻探討 3
第一節 現代醫學對於失血的研究論述 3
       一、失血對機體之影響 3
二、失血的分期與表現 6
三、失血的治療與處理 8
    第二節 中醫對於亡血證之相關論述 11
       一、病名源流與定義 11
       二、病機轉化 12
第三節  藏象學說的現代研究 15
       一、藏象學說研究 15
       二、器官共振理論 19
       三、近代脈波頻譜分析研究 21
第四節 急性失血模型之探討 39
第三章 材料與方法 31
   一、實驗對象 31
   二、手術器具 31
   三、實驗試劑 31
   四、實驗儀器 31
   五、實驗前動物之準備 32
   六、實驗步驟 32
   七、血壓波之分析 32
   八、統計分析 33
第四章 結果 35
第一節 實驗用大鼠之基本資料 35
第二節 大鼠放血後各時間點血壓波時域各統計值之變化 36
第三節 大鼠放血後各時間點血壓波頻域各統計值之變化 44
第五章 討論 61
第六章 結論與建議 65
參考文獻 66
英文摘要 70
謝辭
表目錄
表一 實驗用大鼠之基本資料比較 35
表二 收縮壓(SBP)於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 37
表三 舒張壓(DBP)於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 39
表四 平均動脈壓(MAP)於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較
41
表五 脈搏壓(PP)於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 43
表六 DC原始值於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 45
表七 C0值於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 46
表八 C1值於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 48
表九 C2值於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 50
表十 C3值於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 52
表十一 C4值於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 54
表十二 C5值於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 56
表十三 C6值於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 58
表十四 C7值於大鼠放血後依存活狀態在各時間點之比較與各時間點間之比較 60
圖目錄
圖一 放血實驗步驟 34
圖二 放血後各時間點收縮壓(SBP)之變化 36
圖三 放血後各時間點舒張壓(DBP)之變化 38
圖四 放血後各時間點平均動脈壓(MAP)之變化 40
圖五 放血後各時間點脈搏壓(PP)之變化 42
圖六 放血後各時間點DC值之變化 44
圖七 各時間點動脈壓C1值之差值變化百分比 47
圖八 各時間點動脈壓C2值之差值變化百分比 49
圖九 各時間點動脈壓C3值之差值變化百分比 51
圖十 各時間點動脈壓C4值之差值變化百分比 53
圖十一 各時間點動脈壓C5值之差值變化百分比 55
圖十二 各時間點動脈壓C6值之差值變化百分比 57
圖十三 各時間點動脈壓C7值之差值變化百分比 59


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Keri E. Moore:Pathophysiologic Characteristics of Hypovolemic Shock.。 The
Veterinary Clinics of North America. Small Animal Practice 2001;31(6):1115-
1128.
Wang Lin YY: Alterations of pulse by Chinese herb medicine。American. Journal
of Chinese Medicine. 1992;20: 181-190.
Wang WK: Some foudation of pulse feeling in Chinese medicine. In Young, W.J. (
ed.): Advance in Biomedical engineering. Hemisphere, Washington D.C. 1989
;pp. 268-275。
Young ST:Specific frequency properties of renal and superior mesentric
arterial beds in rats。Cardiovascular Research 1989;23(6):465-467.

----------------

第 14 筆
國家圖書館索書號: 系統編號: 91NCKU5442161
     出版年: 民2003/07/29
     研究生: 葉人豪 Jen-Hao Yeh
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 都卜勒超音波系統在微小振動頻率及生物體器官微共振模擬系統量
測之應用
    論文名稱: Application of Doppler Ultrasonic System for Measuring
the Frequency of Micro-Vibration and the Phenomenon of An
Organ's Micro-Vibration Emulator
    指導教授: 楊明興 Ming-Shing Young
    學位類別: 碩士
    校院名稱: 國立成功大學
    系所名稱: 電機工程學系碩博士班
     學年度: 91
     語文別: 中文
    論文頁數: 85
     關鍵字: 超音波 Micro-vibration
脈波/回音 Doppler
都卜勒 Pulse/Echo
微共振 Ultrasonic
[摘要]
   共振是自然界的一種現象,由王唯工教授和林玉英教授所提出的器官血管叢共振理
論可以得知人體的器官也會隨著脈搏有共振的現象,人體中各內臟器官都有其專屬的動脈
血管叢系統,當血液隨著脈搏跳動而流入器官時,在血管叢中會產生共振現象,進而引發
該器官本身機械式的微振動現象,且各器官有不同的共振頻率,使整個循環系統和諧穩定
,當器官受到外來刺激時,器官的共振頻率受影響而改變。
   為了研究振動,本論文先建立一套脈波/回音式超音波量測系統,探討此系統在量測
距離、振動大小及振動頻率的能力,並將此系統應用在量測生物表面較大的振動(如呼吸、
發抖)。為了更進一步量測生物體內器官微小共振的頻率,希望能推知器官在正常或有外來
刺激情況下二者不同的反應,我們再建立一套都卜勒超音波量測系統。由於器官共振頻率
的特徵是以心臟的基頻及其諧波所組成(目前已知到第十諧波),因此量測頻率的範圍約
從1.2Hz到12Hz左右。我們以訊號產生器來產生模擬器官微小振動的頻率,研究都卜勒系統
在量測振動頻率及位移速度的能力。本論文所有的量測皆以精密的雷射變位計量測系統作
為校正及驗證的依據,將量測的結果則以LabVIEW程式擷取並分析,比較量測系統與驗證系
統的量測結果以分析量測系統的量測能力與量測誤差。


[摘要]
   Resonance is a phenomenon of physics. From the theory of “The Resonance
Effect on Blood Pressure and Flow Hypothesis” presented by W.K. Wang and Y.Y.
Lin, we know there are resonant frequencies in vitals. When the blood flows
into organ along with pulse vibration, blood plexus not only has resonance
phenomenon, but also initiates organ’s mechanical micro-vibration by itself.
Each organ has its special principal resonant frequency; the circulatory
system is harmonious and stable. When organ under excitation, the resonance
frequency changes.
   Our study is to develop a measurement system for detecting resonant
frequency. We want to infer the difference responses when the organ is at
normal or excitation state. These resonance frequency have a characteristic
from 1.2Hz to 12Hz, it have a low frequency and small displacement. Our
doppler system has a good estimation for simulated organ micro-vibration 
frequency, and we use a laser displacement measurement to rectify and verify.


[論文目次]
 目 錄
 中文摘要   Ⅰ
 英文摘要     Ⅱ
 誌謝     Ⅲ
 目錄              Ⅳ
 表目錄     Ⅶ
 圖目錄     Ⅷ
 第一章 緒論        1
 1.1 研究動機與目的       1
 1.2 內容架構     3
 第二章 系統原理及設計     5
 2.1 脈波/回音式超音波量測系統     5
  2.1.1 脈波/回音式超音波量測原理     5
  2.1.2 脈波/回音式超音波量測系統設計     7
  2.1.3 脈波/回音式超音波量測系統電路    11
  2.1.4 量測結果擷取及分析軟體流程      17
 2.2 都卜勒超音波量測系統     23
  2.2.1 都卜勒超音波量測原理     23
  2.2.2 都卜勒超音波量測系統設計27
  2.2.3量測結果擷取及分析軟體流程    36
 2.3 振動模擬系統       39
 2.4 雷射變位計校正及驗證系統40
  2.4.1 雷射變位計量測系統設計 40
  2.4.2 驗證系統結果分析軟體流程43
 第三章 系統測試及結果 46
 3.1 脈波/回音式超音波量測系統測試結果  46
 3.2 都卜勒超音波量測系統測試結果   51
 第四章 討論    54
 4.1 脈波/回音式超音波量測系統結果及討論  54
  4.1.1 量測振幅誤差分析      54
  4.1.2 量測頻率誤差分析  56
  4.1.3 量測振動誤差分析      59
 4.2 都卜勒超音波量測系統結果及討論   62
  4.2.1 量測頻率誤差分析  62
  4.2.2 量測速度誤差分析      64
 第五章 結論    68
 參考文獻70
 附錄 73
 附錄A 400ET/R180超音波感知器的特性規格   73
 附錄B 16 Characters × 2 Lines LCD模組規格  75
 附錄C Multi Dopplex II詳細規格       76
 附錄D OMRON ZX-LD100雷射變位計詳細規格   77
 附錄E 脈波/回音式超音波量測系統整體電路圖 78
 附錄F LabVIEW完整程式   79
 附錄G 系統照片   82
 自述     85


[參考文獻]
 [1]S.T. Young, W.K. Wang, L.S. Chang. and T.S. Kuo, "Specific frequency
properties of renal and superior mesenteric arterial beds in rates",
Cardiovasc. Res., 23(6), 465-467, 1989
 [2]Y.Y. Lin, C.C. Chang, J.C. Chen, H. Hsiu and W.K. Wang, "Pressure Wave
Propagation in Arteries- A model with radial dilatation for Simulating the
behavior of a real artery", IEEE Engineering in medicine and Biology, pp.51-
56, Jan./Feb., 1997
 [3]王唯工,氣的樂章,大塊文化,臺北市,2002
 [4]林宏益,脈波/回音式超音波器官微共振量測系統/A pulse-echo ultrasonic
system for measuring micro-vibration of organ in resonance/,國立成功大學電機工
程學系碩士論文,民91
 [5]侯春茹,設計及發展一套脈波式都卜勒超音波系統量測軟組織之黏彈特性/Design
and development of a pulsed wave doppler ultrasonic system for measuring the
viscoelasticity of soft tissue/,國立成功大學醫學工程研究所博士論文,民91
 [6]K.J. Parker, S.R. Huang, R.A. Musulin, and R.M. Lerner, "Tissue response
to mechanical vibration for Sonoelasticity imaging", Ultrasound Med. Biol.,
vol. 16, no. 3, pp. 241-246, 1990
 [7]R.M. Lerner, S.R. Huang, and K.J. Parker, "Sonoelasticity images derived
from ultrasound signals in mechanical vibrated tissues", Ultrasound Med.
Biol., vol. 16, no. 3, pp. 231-239, 1990
 [8]唐新民,超音波入門及應用,無線電界雜誌社,中和,1996
 [9]K. Ikeda, "Ultrasonic Measurement of Sound Velocity in Liquids which
Automatically Eliminates Temperature Dependence", IEEE Conference on
Ultrasonic Symposium, 1998
 [10]Štefan Kociš, "Ultrasonic Measurements and Technologies", pp.
63-66, Chapman & Hall, UK, 1996
 [11]R.A. Witte, "Electronic Test Instruments", Prentice Hall PTR, 2002
 [12]吳金戍、郭庭吉、沈慶陽,8051 單晶片微電腦實習與應用,松崗,臺北市,1993
 [13]謝勝治,圖控程式語言 LabVIEW,全華,臺北市,2003
 [14]蕭子健、林俊宏、彭宇豪,LabVIEW 硬體介面篇,高立,臺北縣五股鄉,2002
 [15]蕭子健、周森益、鄭博修、林珮瑜、黃欽章,LabVIEW 分析篇,高立,臺北市
,2000
 [16]http://www.huntleigh-healthcare.com/
 [17]http://www.omron.com/
 [18]http://www.ni.com/
 [19]National Instruments Corporation, Data Acquisition & Signal Conditioning
Course Manual, NI, 2002
 [20]National Instrument Corporation, DAQ 6023E/6024E/6025E User Manual,
National Instruments, NI, 1999
↑回到頂端↑
#415406 - 2004-09-09 15:55:05 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com

第 筆
第 4 筆
國家圖書館索書號: 系統編號: 92NTU00442008
     出版年: 民93
     研究生: 郭玉誠 yu-cheng,kuo
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    電子全文: 電子全文下載
    論文名稱: 血壓諧波變異係數於醫學工程之應用
    論文名稱: Application of the Coefficient of Variation of the
Harmonic Magnitude (HCV) of the Arterial Pulse in Medical
Engineering
    指導教授: 王唯工 wei-kung,wang
    學位類別: 博士
    校院名稱: 國立臺灣大學
    系所名稱: 電機工程學研究所
      學號: D86921034
     學年度: 92
     語文別: 中文
    論文頁數: 112
     關鍵字: 血壓諧波變異係數 coefficient of harmonic
variation of magnitude
諧波穩定性 harmonic stability
系統崩潰 system failure
多重器官病變與衰竭 multi-organ disorder or
failure
死亡過程 dying process
[摘要]
當代高居十大死亡病因的重大疾病發展至疾病後期,均會發生多重器官病變與衰竭之系統
性影響。若以醫學工程的角度而言,系統崩潰是這些疾病共同的致病機轉與結果。
醫學工程以系統的觀點,運用各工程領域知識,透過定量生理分析與儀器設計,以解決臨
床上的問題。因此設計了動物與臨床兩個瀕死實驗,並且發現血壓諧波變異係數於死亡過
程中從高頻逐漸增加再一一擴及往低頻逐漸增加,逐步喪失諧波穩定性。證明血壓諧波變
異係數可以作為死亡過程中,系統崩潰的定量生理指標。並且透過非侵入性儀器的設計與
評估,驗證血壓諧波變異係數應用於新醫療儀器開發的評估指標可能性。
血壓諧波變異係數在不同階段疾病與死亡過程呈現出系統化的定量變化,使傳統醫學由脈
學診斷建立的系統觀得以確定;並提供中西醫學整合的平臺;更為重大疾病的防治指引新
方向。


[摘要]
The top ten mortality causes in twenty-one century, nearly all lead to
systemic multi-organ disorder or failure in the last stage. In the point view
of medical engineering, system failure is the general mechanism and ending of
these causes.
Thought the quantitatively physiological analysis and medical device design,
medical engineering utilizes systemic thinking and engineer knowledge to solve
the clinical problems;therefore, we designed animal and clinic experiments to
evaluate the coefficient of harmonic variation of magnitude (HCVs) and found
that all the harmonic components gradually lost their stability during dying
process. The HCVs, which increased first for the high-frequency components and
then the low-frequency components, could quantitatively reflect the process of
system failure. Meanwhile, through the design and evaluation of a noninvasive
device, we proved the HCVs’ ability applied to the new medical device
development.
The HCVs,which systematically and quantitatively indicates the severity of
different stages of illness and dying process,confirms the Chinese medical
system established from pulse diagnosis and provides the fundamental to the
integration of medicine;moreover, could indicate a new way to cure the top
ten mortality diseases in our time.


[論文目次]
目錄:
中文摘要
英文摘要
第一章:緒論                  1
第二章:血壓諧波變異係數與徑向共振理論    18
第三章:血壓諧波變異係數於動物實驗之定量生理分析研究              
28
第四章:血壓諧波變異係數於臨床之定量生理分析研究與應用             
57
第五章:血壓諧波變異係數於醫療儀器開發之應用 73
第六章:血壓諧波變異係數於傳統醫學科學化與醫學工程之應用            
91
第七章:討論與未來展望            97
參考資料                  102
第一章: 緒論
1-1多器官病變之系統疾病的威脅
1-2循環系統的重要性
1- 3西方醫學在循環系統上的瓶頸
1-4 傳統醫學的整體系統觀
1-5 以循環系統為核心的傳統醫學
第二章: 血壓諧波變異係數與徑向共振理論
2-1徑向共振理論為核心的系統觀
2-2徑向共振理論於臨床醫學上的應用
2- 3血壓諧波變異係數的定義
2-4血壓諧波變異係數的生理意義
第三章:血壓諧波變異係數於動物實驗之定量生理分析研究
3-1 實驗設計與實驗方法
3-2 實驗結果
3-3 實驗分析與討論
3-4 血壓諧波變異係數與心跳變異率之比較
第四章:血壓諧波變異係數於臨床之定量生理分析研究與應用
4-1 實驗設計與實驗方法
4-2 實驗結果
4-3 實驗分析與討論
4-3 血壓諧波變異係數於臨床之應用
第五章:血壓諧波變異係數於醫療儀器開發之應用
5-1非侵入式左心室輔助器之設計
5-2非侵入式左心室輔助器之生理評估
5-3非侵入式左心室輔助器之改進與再評估
5-4臨床實驗分析與討論
第六章:血壓諧波變異係數於傳統醫學科學化與醫學工程之應用
6-1血壓諧波變異係數與傳統醫學診斷之定量
6-2傳統醫學科學化之研究與醫學工程之建構
6-3傳統醫學科學化與創新研究
第七章:討論與未來展望
7-1血壓諧波變異係數與臨床醫學之系統整合
7-2血壓諧波變異係數與中西醫學整合
7-3血壓諧波變異係數的未來研究計畫


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↑回到頂端↑
#415407 - 2004-09-13 11:30:04 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
呵呵 dh 那邊的 anonymous 大師提的問題,
小弟一時熊熊也不知道該怎麼回答才好.

-----------

王氏諧波產生順序 胚胎學上器官發育的順序
心 心(第21天)
肝 肝(第三週中期)
腎 肺(第三週)
脾 膽囊(第四週)
肺 胃(第四週)
胃 腎(第五週初期)
膽 脾(第五週)
膀胱 大腸(第六週)
大腸 膀胱(第七週期)

那ㄟ安ㄋㄟ

-----------

其實胚胎成長過程一直是很重要的主題,
理由很簡單, 如果從現有身體的證象,
歸納出屬於某臟某腑某經某絡的症候群,
而臟腑經絡之間互相影響動態平衡也抓出來了,
接下來很自然就會想: " 為什麼會有這樣的現象 ? "

治病必求其本,
很自然就會想去知道臟腑經絡的生成原因與次序,
假設人體也像洋蔥那樣一層一層的往外成長的話,
那外面邪氣要攻擊進來, 如果沒有內傷, 那就也得那樣一層一層的突破.
而萬一正氣虛, 邪氣實, 裡面有作亂的內傷, 外面有外感的敵人,
也是得搞清楚到底在那一層, 該怎麼樣調度氣血從外面加資源補氣血,
才能用極有限的資源, 幫助身體解決最多的問題,

像自由出版社出版的" 華陀玄門內照經 "
裡面一開始就在推導胚胎成長過程,
為什麼八字能夠用 ? 為什麼講先天後天精氣神 ?
為什麼挑帝王生產八字總是挑不準 ?
大概原因都在因果相繫吧.

華陀也很會處方用藥耶 不輸給張仲景說
裡面的思維遠超過現在所謂的臟腑辨證
應該說是" 胎息辨證 "吧

體質也好, 八字也好, 似乎在出生前就已經環環相扣,
相關家族環境各種因子一層一層從低頻往高頻疊加上去,
最後出生的那個點其實根本不是偶然 ....

這或許也就是為什麼小弟每次幫人家挑了所謂的" 好八字 ",
多半都沒有機會用到, 都是提早就出生了 .....
↑回到頂端↑
#415408 - 2004-09-13 12:47:56 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
hm 小弟把電話 email 給您了
看看您還有什麼想要的書
小弟 9.25 回彰化就一起帶來台北印一份囉.

如果時間允許的話,
小弟把手邊自己整理的一些筆記與家族命譜,
也印一份給您好了.

其實醫學這邊東東還可以探討到胚胎形成過程,
也就是八字為什麼會在這樣子的時刻誕生,
" 八字是我, 我是八字, 八字之前, 我是什麼 ? "

癸海前輩( fun123 ) 是講:
" 八字非我, 我非八字, 沒有八字, 我還是我. "


當初研究鐵板也不過是想知道六親遺傳的大自然規律,
這對以數術模式來描述人的生命週期有很大幫助,
像是抓到了牛頓運動定律就可以設計一堆東東說.

小弟相信像這樣的東東應該是無所不在的,

" 道不可須臾離也, 可須臾離者非道. "

既然是這般低頻無時無刻都存在的現象,
不可能只有鐵板這邊能發現, 而其他領域一無所知.

如果醫學那邊能夠找到解答, 而且有全套完整的應用方法,
就像電鍋微波爐電磁爐瓦斯爐取代古代的灶一樣,
坦白說, 許多東東就只剩下懷舊的歷史考古價值了,
也像我們今天用的是電腦, 而不是用古代的算籌算盤,
去推導大自然的相關理論

------

釘釘兄見過高平子前輩阿 wa ...
看" 高平子曆法天文著作選 "裡面是講原本是兩本書沒錯,
後來他的小孩還是科學月刊就把這兩本書整理成一本
就是上面提到的這本, 原本的兩本就變成絕版書了.

數學月刊在中研院數學所, 網路上面可以查的到電話,
或許釘釘兄可以直接發 email 或打電話去問.

小弟第一次看到這本書的名字是在王中和前輩貼的文章裡,
第二次是看到曹亮吉教授在" 阿草的曆史故事 "裡面
講到曆法校定與史記天官書的故事, 後來在彰化家裡那邊,
看到這兩本書就靜靜在書局架上躺了很久, 一發現如獲至寶,
就一口氣全買了.

架上應該還有 3 本, 可是後來再去就全不見了,
不知道是被買走, 還是退回去了說.

想想網路真是有意思的東東,
把全世界的同好串在一起, 真是讓人興奮阿

蠻像是昨晚一口氣看完的" 達文西密碼 "一般 !!

其實就像徑向共振理論串結所有臟腑經絡的共振,
八字應該就是串結整個家族命運共同體的模式吧.

----------

"鐵板"數的文章都在" 陰陽五行 "討論區那邊,
寫了一堆, 或許有興趣的再用搜尋功能喵一喵囉

跟天下出版的" 阿草的數學故事 "
還有" 大自然的數學遊戲 "" 生物世界的數學遊戲 "一樣,
大家在找的都是一樣的東東, 在找上帝當初在想什麼

小弟發現古人在數術中醫這邊努力了這麼久,
不可能一無所有 .....
↑回到頂端↑
#415409 - 2004-09-16 16:30:18 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
[From: Cln@] - Wed Sep 15 12:55:03 2004


原出處:2002/07/03 民生報A4版/生活新聞 鍾蓮芳報導

中央研究院院士會議為了醫學院應否編入加強中醫教育課程,引起院士們對中醫
藥臨床「實證」療效的激辯,部分學西醫的院士認為,中醫是模糊的科學不應鼓勵,
還讓討論氣氛一度轉趨緊張。中醫藥到底療效如何?中研院院長李遠哲以自己治偏頭
痛為例,終結這個爭議。

[Cln按: 在氣的樂章附錄也有提到這件事, 國外院士覺得很奇怪的那一段]

李遠哲說,他二、三年前飽受偏頭痛之苦,進出台大醫院不計其數,就是無法根
治。後來,他聽朋友說,來自日本的國寶級中醫來台,特別去把脈,醫師開了二十幾
種藥的方子,叫他去迪化街抓藥吃,結果因為他太太煎藥時,把一些看起來像蟲的藥
丟了,他想藥效可能沒有了,就沒有喝那帖藥。

偏頭痛沒有好,他又接受朋友建議,看了另一名中醫。這次中醫說,只是氣血不
順,幫他按摩了半小時,偏頭痛就好了。他還特別拿了前一中醫開的方子給這個中醫
看,這個中醫說,「要下這麼重的藥嗎?」

李遠哲說,西醫沒有解決他的問題,中醫治好他的病,但是不可否認,他也可能
被前一個中醫害了。所以,做為一人,不管西醫或中醫,治癒病人都還有盲點。

[Cln按: 醫生的程度跟能力應該區分開來, 如果從學理上治得好的問題,
臨床上沒被治好, 就該考慮該醫生的程度問題. 西醫學上能否治偏頭痛
小弟不曉得, 不置評. 至於後段, 也不過就是一個會推拿的中醫師治好了,
只會開方藥的那位沒治好(甚至連藥都還沒吃!!??), 純粹只是醫生程度問題
卻牽拖到[中醫學]上頭..]

-------------

[From: j5@d82044@video.ee.ntu.edu.tw] - Thu Sep 16 16:19:29 2004


呵呵 剛剛一邊 debug 一邊想
原來中研院院士關於中醫的投票
也是在低頻高頻的常態分布裡面

理由很簡單阿

全世界最強的大概都跑去美國了
不管哪個領域都是這樣
一堆小弟超級厲害 100 倍的同學
也都跑去那邊唸書工作生活住在那邊

所以在美國的中研院院士發現西方醫學解不掉的難題
怎麼那些去美國執業的中醫一個個改善解掉

這很像看到自信滿滿船堅炮利的老外 用盡腦力邏輯研究出物理定律
可是看到怎麼有人可以一打坐就浮起來 違反地心引力那樣不可思議
像 homa 大師的針灸老師那般前輩高人 也持續在那邊表演奇蹟
自然他們會回來呼籲應該回頭重視中醫這塊寶貴的經驗

可是在台灣的中研院院士回來住久了
發現奇怪 怎麼老是遇到問題還是得靠西醫去解
電視上的廣告的中醫老是在講自己壯陽補肝豐胸賣減肥藥
一付就跟第四台算命的講股票的 0204 的無敵美少女沒啥兩樣
自然就強烈反對把中醫這種反智的東東納入教材

-----

沒辦法
一邊看到的是高頻高檔藝術家 頂尖高手
一邊看到的是為求生存什麼怪招盡出的江湖郎中
自然沒辦法達成共識了 ......

而好玩的是李遠哲院長隨便抽樣
就得到分佈在幾個不同區間樣本

國寶級的當然要開一帖見效入臟的方子
不然哪來的時間看第二次 ?

而幫院長抓龍的大概是熟識的好友
朋友碰碰面邊聊邊抓 心情輕鬆愉快
自然就覺得好的很快

西藥為什麼沒效阿 呵呵 因為心病要用心藥醫阿
保證李遠哲院長現在的頭肯定還是常常會痛拉
那麼多奇奇怪怪的鳥事來煩 不頭痛才有鬼~~~
↑回到頂端↑
#415410 - 2004-09-17 01:02:05 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
所以同學見面老問小弟
要小弟幫忙看八字 看看可不可以開業
小弟都說請他回去問他爸爸 因為他爸爸是公司總經理
做生意做的非常成功賺很多錢

開業其實就是開店做生意吧
不要想的太過複雜 哈哈 ...

------

剛剛下班拖著一箱的書回家, 邊走邊想,

" 呵呵, 真的是台灣的中醫師比較不行嗎 ? "

想想好像也不盡然是如此, 平平都是橘子,
長在不同地方就變成不同的模樣, 不是嗎 ?

每天早上都會經過一家全省連鎖最大的眼科,
呵呵, 那個眼科還有附咖啡屋的勒,
身邊好些人去看眼睛毛病,
就會有 sales 護士過來跟你推銷開近視刀.

當然 homa 大師說這種刀經歷了 20 年的考驗,
到目前為止還沒出現大問題, 算是自費裡面高收入的來源,
不過好像在台灣除了有低頻的實力之外,
還得像 fashion show 那樣搞一堆包裝的花招.

晚上走路回家常會經過一家中醫診所,
旁邊對照組是號稱到國外留學的西醫小兒科診所.

那家中醫診所其實亂像對面做女子美容的,
花招百出耶, 人也很多喔,
天天經過滿屋子坐在那邊身上扎著針照紅外線燈的人.

那家中醫診所常常有新花招, 一下子有減肥丸子,
一下子增聘什麼高手駐診, 還列出高手在那邊演講的公告,
還有喔, 還有好像薰臍流行就加增薰臍療程, 很多啦.

旁邊西醫診所就好像比較沒什麼人, 常常看座位是空的.
隔一條街對面的牙醫診所還是教授勒,
可是走過去看他跟護士在那邊看電視.

可見中醫師的生意是不錯的喔, 才付的起一個月 20 萬的薪水.

-------

所以想想, 老外看到的中醫師真的就是扁鵲華陀倉公仲景再世嗎 ?
再世或許也治不好傅培梅, 套句 homa 大師說的:

" 照古人的醫療經驗, 傅大師或許早就掛掉 3,5 次以上了.
你怎麼可能帶一個古人經驗中早就過世的人給前輩大師看 ? "

或許是對照近代醫學的死角,
剛好中醫前輩高人經驗的探照燈探索過那邊的解法,
像 cpu 本來就能比 asic 解比較多的問題,
在西方的社會環境相形之下顯的變成超人.

而在台灣的中醫功力就真的是那麼遜嗎, 或許也不盡然,
或許是被整個環境逼到得急功近利, 立竿見影, 療效顯著,
而不管短視近利之後的結果會是怎樣.

以前家裡那邊有個鄰居,
她都會去幫家裡那邊生意最好的小兒科診所算錢記帳,
有一次她們親戚家人生病, 她就跟醫生描述了症狀拿藥回來.

好死不死要吃前, 被剛回家在醫學院實習的好友小孩看到,
那個小孩看到嚇死了, 就說那個藥的劑量強度是教科書上建議劑量的 2,3 倍,
那樣子吃會有危險, 結果直直阻止她們吃.

後來又過了幾年, 換那個好友小孩自己出來開業,
她就跟她媽媽說當年她錯了, 因為如果不那樣子開藥,
病人會嫌你沒有效, 怎麼沒有吃一次就好.

接下來就是門可羅雀, 直到她也做了跟當年醫生一樣的事之後,
生意才又慢慢回到溫飽狀態, 還有媽媽拼命帶小孩來,
直豎起大姆指說: " 有效 !! 吃你的藥真有效 !! 一包就好了 !! "

.........
↑回到頂端↑
#415411 - 2004-09-17 10:30:04 Re: 王唯工教授的論文摘要整理
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
↑回到頂端↑
#415412 - 2004-09-20 20:20:19 死生之域
jfive 離線
一元復始
註冊: 2003-04-16
文章數: 1169
來自: hemingwang.blogspot.com
第 14 筆
國家圖書館索書號: 系統編號: 87NTU00493008
     研究生: 李建民 Li Jian-min
(以研究生姓名查詢國家圖書館索書號 ,未查獲者表國圖尚未典藏)
(以研究生姓名查詢國科會科資中心微片資料庫)
(連結至全國圖書聯合目錄)  (連結至政大圖書館館藏目錄)
    論文名稱: 死生之域──周秦漢脈學之源流
    指導教授: 阮芝生 Ruaan Jy-sheng
    學位類別: 博士
    校院名稱: 國立臺灣大學
    系所名稱: 歷史學研究所
      學號: D80103002
     學年度: 87
     語文別: 中文
    論文頁數: 374
     關鍵字: 脈
數術
醫學
周秦變革期
生命醫療史
全文影像: (依著作權法相關規定,以下全文影像僅限國家圖書館館內下載)
封面
謝辭
提要
目次
第一章 導論
第一節 死生之域--由扁鵲醫案引出的醫史課題
第二節 新出土文物與醫史研究
第三節 脈學多源與針炙失傳論─問題意識
第二章 周秦變革期--經脈體系的分期概念
第一節 醫學三變
第二節 方技四支與三系
第三節 古脈分域
第四節 禁方傳統--師資、文本與驗效
第五節 小結
第三章 醫在天官--經脈學說的王官傳統
第一節「天有宿度,地有經水」:脈的循行
第二節 天官與天數:《左氏》秦和傳發微
第三節 (周禮)醫師-系職官
第四節 小結
第四章 脈與導引--生命在運動中
第一節 從禮容的身體到數術的身體
第二節 脈與養形
第三節 (陰陽經)與(導引圖)一脈與養生道論
第四節 脈與房術
第五節 小結
第五章 數術觀的身體
第一節 陰陽與脈序:「天道大數有二,謂五與六」
第二節 脈與藏
第三節 脈與病--「經脈病候」辨證
第四節 小結
第六章 新工具
第一節 「九針」的形成一周秦外冶工具的合流
第二節 脈與工具:「炙刺稽滯,開利百脈」
第三節 「解部」事始一一脈如何被人看見?
第四節 小結
第七章 結論--什麼是「生命醫療史」?
參考書目
圖版
[摘要]
?搘遢蚺撅敦Q中醫經脈學說的源起。所研究的期間是自戰國迄於西漢末,正值中醫知識體
系從眾說紛紜漸趨統一的時代。傳統對經脈觀念緣起的解釋,大致是認為與針灸術有密切
關係。始初先民由經驗認知刺激個別腧穴有療病的功效。九針等工具的出現使腧穴位置與
主治得以確立,遂能依主治性能歸納成經絡體系,乃由點而線累積而成。近年新出土的脈
書與醫史文物顯示這樣的解釋已面臨修正的必要。本文即欲爬梳上古經脈學說的源流,並
探討當時剛出現與脈學相關的新技術、新工具、以及新身體觀。本文將試圖解答以下幾個
問題:什麼是「脈」?這個概念最早出現在何類文獻?此一概念純屬醫學範疇嗎?曾與哪
些醫療技術結合?又是否可能與論脈時無所不在的數術之學割離?最後,新工具在脈學體
系化的過程究竟扮演了什麼角色?
?搘遢蚺撋o現脈是傳統中國醫學最關鍵的概念,但最初脈學並非醫者所獨擅。此外在周、
秦之時也有燕齊、秦蜀、荊楚等三派地域之別,可謂百花齊放。種種脈學著作在多系並存
的情形之下,又都透過依托、密傳以及文本疊壓的方式流傳下來。而更重要的是,脈學的
大傳統隨著不同時代又各有顯著特色。本論文將上古脈學史分析為「王官」、「方者」、
以及「醫經」三個時代,並以此架構闡述脈學的發展。
?搷痡N脈學體系化的過程稱為數術化的程序。易言之,它從一些零散的醫學經驗躍升為體
系性的學問的過程中,是建立在氣、陰陽、五行以及感應等數術概念之上的。脈概念的萌
發延續了兩種人體的知識,醫者由人體多處搏動之處「脈診」逐步延伸為脈循行的最初路
線;此外由刮除體表膿血的「啟脈」技術的經驗,類推出伏行體內有脈。這就是後世所謂
「經脈」概念的雛形。而將這些經驗理論化是依賴數術及天人感應,隨著規律性天文知識
的成熟,「王官」時代的人們也相信脈在人體的流注也一定有相應的宇宙秩序。方者接受
了這個新的身體觀以身按驗,在身體模擬天地運行的過程,發展出導引、行氣等新的技術
。他們認為人體的氣與天道宇宙的規律一樣,隨著時間與方位之別而有盛衰變化,這種變
化的規律是可以用陰陽、五行、干支等符號表述,甚至於推算或預測。本論文稱此為「數
術的身體觀」。從此再進一步發展成一個周而復始、循環不息的宇宙形式,這個宇宙有固
定的循環方向;循環動力的來源被認為是與某個臟器有關;同時,由觀察循環的週期與強
弱可以推知整體運行是否正常。所謂「脈」,正是人體宇宙循環的軌道,有如天體、水道
運行的路徑。也有如天官可由災異推知天體的失序,都水可由氾濫察知水道的鬱滯,醫者
也可以用脈象失常來診斷人體的疾病。所以脈的概念是這個新身體觀的核心,是「所以能
決死生」的基準。這個身體觀成為傳統中醫學的基礎。今日對於經脈體系的認知相對於傳
統中醫學已有差異,這個差異不但是因為氣、陰陽、五行、感應等個別概念的變化,更是
由於整個數術的宇宙論的崩潰。宇宙論概念的崩潰也致使現代人的身體經驗產生變化。我
們今日研究這個無法目驗,亦不能以現代解剖學解釋的脈,其意義在於提供另外一種了解
生命或人體的範式。
?搹馴~,本論文認為針灸療法與脈學有密切關係。今日討論脈的發現與產生,往往太重視
針具的角色。針灸療法從刺經到刺穴的轉變,無疑與工具的進步有關。但那已是在脈學體
系化較晚的下一個階段。針具的進化導致腧穴性質與位置的確定,也對於脈從獨立演變至
經不離穴的概念也產生了重大的影響。


[參考文獻]
參 考 書 目
(一)傳統醫籍(包括點校、譯注、輯佚、景印醫籍)
丁光迪主編,《諸病源候論校注》(北京:人民衛生出版社,1994)。
小曾戶洋監修,《仁和寺本黃帝內經太素》(大阪:東洋醫學研究會,1981)。
中莖謙,《扁鵲傳正解》(文政六年〔1823年〕晛齊藏板本)。
丹波元簡等編,《素問識‧素問紹識‧靈樞識‧難經疏證》(北京:人民衛生出版社
,1984)。
丹波元簡,《扁鵲倉公傳彙考》(存誠藥室藏本)。
丹波康賴,《醫心方》(北京:華夏出版社,1993)。
片倉元周,《青囊瑣探》,收入《皇漢醫學叢書》第13冊(高雄:平凡出版社影印本)。
牛兵占等,《中醫經典通釋:黃帝內經》(石家莊:河北科學技術出版社,1994)。
王叔和,《脈經》(北京:中國醫藥科技出版社,1998)。
王肯堂彙輯,《醫統正脈全書》(台北:新文豐出版公司影印,1975)。
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